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PS 48
Axon 1659
CAS:
1180676-32-7
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C17H15ClO2
- MW: 286.75
Description
Allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1 or PDK1). PS 48 has a Z-configuration in comparison with its inactive E-isomer PS 47 (Axon 1664)
More Information
| Parent CAS No. | 1180676-32-7 |
|---|---|
| Chemical Name | (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid |
| SMILES | C1C=C(CC/C(=C/C(=O)O)/C2C=CC=CC=2)C=CC=1Cl |
| MFCD | MFCD17215962 |
| InChi | InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12- |
| InChiKey | LLJYFDRQFPQGNY-QINSGFPZSA-N |
| CID | 44141940 |
| Short Description | PDK1 activator |
References
- A Stroba et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding (...). J. Med. Chem. 2009, 52(15), 4683-93.
- V Hindie et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nature Chem. Biol. 2009, 5, 758-764.
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