Necrostatin-1

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1258

CAS [4311-88-0]

MF C13H13N3OS
MW 259.33

Purity: 99%
Soluble in DMSO

Necrostatin-1

Description

A cell-permeable, potent, and selective inhibitor of necroptosis; Acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity

A. Degterev et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chem. Biol. 2008, 4, 313-321.

A. Degterev et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chem. Biol. 2005, 1, 112.

Apoptosis Cell Signaling & Oncology Immunology Pain & Inflammation NF-κB MAPK DNA-damage Response EC 2.7.11.1 RIP

RIP1 inhibitor

Chemical name

5-((1H-indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one

Parent CAS No.

[4311-88-0]

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Size	Unit Price	Stock
25 mg	€95.00	In Stock
100 mg	€285.00	In Stock

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