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GBR 12783 dihydrochloride
Axon 1203
- Parent CAS: 67469-57-2
Purity:
99%
- Soluble in water and DMSO
- MF: C28H32N2O.2HCl
- MW: 485.49
Description
GBR 12783 dihydrochloride is a potent and selective dopamine uptake inhibitor that blocks dopamine transporter (DAT)-mediated reuptake and increases dopaminergic tone in transporter-based assays.
DAT controls extracellular dopamine availability in nigrostriatal, mesolimbic and mesocortical pathways. GBR 12783 is useful for dissecting dopamine transporter function, stimulant-like pharmacology and catecholamine-dependent signaling in CNS research.
Key Features
- Selective inhibitor of dopamine uptake
- Targets dopamine transporter-mediated reuptake
- Useful tool for dopaminergic neurotransmission studies
- Supports analysis of catecholamine signaling and transporter pharmacology
Applications
- Dopamine transporter (DAT) uptake assays
- Dopaminergic neurotransmission research
- Reward, locomotor and psychostimulant pathway studies
- Catecholamine transporter pharmacology
More Information
| Parent CAS No. | 67469-57-2 |
|---|---|
| Chemical Name | 1-(2-Benzhydryloxy-ethyl)-4-((E)-3-phenyl-allyl)-piperazine dihydrochloride |
| SMILES | C(OCCN1CCN(C/C=C/C2=CC=CC=C2)CC1)(C1=CC=CC=C1)C1=CC=CC=C1.Cl.Cl |
| MFCD | MFCD00209830 |
| InChi | InChI=1S/C28H32N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;;/h1-17,28H,18-24H2;2*1H/b13-10+;; |
| InChiKey | HJDXBLLTRMCYNC-JFXLULTRSA-N |
| CID | 24744862 |
| Short Description | DA uptake inhibitor |
GBR 12783 dihydrochloride
dopamine transporter inhibitor
GBR12783
GBR-12783
SLC6A3
dopamine transporter
Inhibitor
dopamine signaling
Dopamine transporter (DAT) uptake assays
Dopaminergic neurotransmission research
Reward and locomotor and psychostimulant pathway studies
Catecholamine transporter pharmacology
addiction research
transporter pharmacology
receptor selectivity
signal transduction
enzyme pharmacology
CNS
CAS 67469-57-2
CAS 67469-75-4
Axon Medchem
Axon 1203
Supplier
Vendor
References
- Bonnet and Constentin. GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. Eur. J. Pharmacol. 1986, 121199.
- Do-Rego et al. Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of dopamine. J. Neurochem. 1999, 72, 396.
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