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(±)-Epibatidine dihydrochloride
- Parent CAS: 148152-66-3
- Soluble in water and DMSO
- MF: C11H13ClN2.2HCl
- MW: 281.61
Description
(±)-Epibatidine is a highly potent nicotinic acetylcholine receptor agonist and non-narcotic analgesic research compound. The enantiopure (+)-epibatidine (Axon 1077) and (-)-epibatidine (Axon 1078) forms are available for stereoselective receptor pharmacology.
Nicotinic acetylcholine receptors regulate fast synaptic transmission, autonomic signaling and pain-related pathways. (±)-Epibatidine dihydrochloride is a high-potency nicotinic agonist used in receptor binding, functional and analgesia-related research models.
Key Features
- Highly potent nicotinic acetylcholine receptor agonist
- (±)-Epibatidine dihydrochloride is the preferred water-soluble salt form of (±)-Epibatidine.
- Non-narcotic analgesic research compound
- Enantiopure forms available for comparison
- Epibatidine dihydrochloride is non-lipophilic and stable, most suitable for laboratory research.
Applications
- Nicotinic receptor pharmacology
- Cholinergic neurotransmission studies
- Analgesia and pain pathway research
- Enantiomer-specific receptor profiling
More Information
| Parent CAS No. | 148152-66-3 |
|---|---|
| Chemical Name | 2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane dihydrochloride |
| SMILES | C1C2CC([H])(C3C=CC(Cl)=NC=3)C(N2)C1.Cl.Cl |
| MFCD | MFCD08705236 |
| InChi | InChI=1S/C11H13ClN2.2ClH/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8;;/h1,4,6,8-10,14H,2-3,5H2;2*1H |
| InChiKey | DGNNWUINALNROG-UHFFFAOYSA-N |
| CID | 21946437 |
| Short Description | Nicotinic agonist |
References
- F Lembeck. Epibatidine: high potency and broad spectrum activity on neuronal and neuromuscular nicotinic acetylcholine receptors. Naunyn Schmiedebergs Arch. Pharmacol. 1999, 359, 378-385.
- MW Decker and MD Meyer. Therapeutic potential of neuronal nicotinic acetylcholine receptor agonists as novel analgesics. Biochem. Pharmacol. 1999, 58, 917-923.
- B. Badio et al. Epibatidine, a potent analgetic and nicotinic agonist. Mol. Pharmacol. 1994, 45, 563-569.
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