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ML417

Axon 3263
CAS:  1386162-69-1
Purity:  99%
  • Soluble in DMSO
  • MF:  C22H25N3O3
  • MW:  379.45

Description

ML417 is a potent, highly selective D3 dopamine receptor agonist with an EC50 value of 38 nM. ML417 promotes potent D3R-mediated β-arrestin translocation, G protein-mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. Also, ML417was found to exhibit neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons.

More Information

Parent CAS No. 1386162-69-1
Chemical Name (1H-Indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone
SMILES N1(C(C2NC3C=CC=CC=3C=2)=O)CCN(CCOC2C=CC(OC)=CC=2)CC1
MFCD MFCD32693923
InChi InChI=1S/C22H25N3O3/c1-27-18-6-8-19(9-7-18)28-15-14-24-10-12-25(13-11-24)22(26)21-16-17-4-2-3-5-20(17)23-21/h2-9,16,23H,10-15H2,1H3
InChiKey HAZPAMUWUHDPDA-UHFFFAOYSA-N
CID 27842480
Short Description D3 agonist

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