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Remodelin
Axon 2299
CAS:
949912-58-7
Purity:
99%
- Soluble in DMSO
- MF: C15H14N4S
- MW: 282.36
Description
Potent Acetyl-transferase NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. Remodelin markedly reduced the prevalence of misshapen nuclei in HGPS cells as well as in primary MRC5 fibroblasts aged in culture. In contrast, Remodelin had no effect on nonlaminopathic Werner syndrome cells
More Information
| Parent CAS No. | 949912-58-7 |
|---|---|
| Chemical Name | 4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile |
| SMILES | C(#N)C1=CC=C(C2=CSC(N/N=C3CCCC3)=N2)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19) |
| InChiKey | XAEJIFARBQJLML-UHFFFAOYSA-N |
| CID | 44442376 |
| Short Description | NAT 10 inhibitor |
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