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GSK 2578215A
Axon 2181
CAS:
1285515-21-0
Purity:
99%
- Soluble in DMSO
- MF: C24H18FN3O2
- MW: 399.42
Description
Potent and exceptionally highly selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values 10.9 and 8.9 nM for wild-type LRRK2 and LRRK2[G2019S] mutant, respectively.) GSK2578215A possesses good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice.
More Information
| Parent CAS No. | 1285515-21-0 |
|---|---|
| Chemical Name | 2-(benzyloxy)-5-(2-fluoropyridin-4-yl)-N-(pyridin-3-yl)benzamide |
| SMILES | C(NC1=CC=CN=C1)(=O)C1=CC(C2C=CN=C(F)C=2)=CC=C1OCC1=CC=CC=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29) |
| InChiKey | WCIGMFCFPXZRMQ-UHFFFAOYSA-N |
| CID | 68107965 |
| Short Description | LRRK2 inhibitor |
References
- A.D. Reith et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg. Med. Chem. Lett. 2012, 22, 5625-5629.
- M.E. Kavanagh et al. The development of CNS-active LRRK2 inhibitors using property-directed optimisation. Bioorg. Med. Chem. Lett. 2013, 23, 3690-3696.
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