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PD90780
Axon 2174
CAS:
77422-99-2
Purity:
99%
- Soluble in DMSO
- MF: C19H14N4O4
- MW: 362.34
Description
A nonpeptide inhibitor of nerve growth factor's binding to the P75 NGF receptor; It binds to NGF, not to the P75 receptor. Differential activity of PD90780 suggests altered NGF-p75NTR interactions in the presence of TrkA.
More Information
| Parent CAS No. | 77422-99-2 |
|---|---|
| Chemical Name | 7-benzamido-4-methyl-9-oxo-4,9-dihydropyrazolo[5,1-b]quinazoline-2-carboxylic acid |
| SMILES | N1(C)C2=C(C=C(NC(=O)C3=CC=CC=C3)C=C2)C(=O)N2N=C(C(O)=O)C=C12 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H14N4O4/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27/h2-10H,1H3,(H,20,24)(H,26,27) |
| InChiKey | IAZAGXDMMVWYKF-UHFFFAOYSA-N |
| CID | 9885305 |
| Short Description | P75 NGF inhibitor |
References
- K Spiegel et al. PD 90780, a nonpeptide inhibitor of nerve growth factor's binding to the P75 NGF receptor. Biochem. Biophys. Res. Comm. 1995, 217, 488-494.
- A Colquhoun et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered (...). J. Pharm. Exp. Ther. 2004, 310, 505-511.
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