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LCS-1
Axon 2176
CAS:
41931-13-9
Purity:
99%
- Soluble in DMSO
- MF: C11H8Cl2N2O
- MW: 255.1
Description
Inhibitor of superoxide dismutase 1 (SOD1). Inhibits SOD1 enzymatic activity in vitro (IC50: 0.19 μM for cell growth inhibition in KRAS mutated H358 cell lines). Conversely, (over-) expression of SOD1 cDNA showed about a threefold reduction in sensitivity to LCS-1 and increased proliferation of H358 cells. Additionally, LCS-1 can prevent serum-induced activation of the ERK and PI 3-kinase/AKT signaling pathways.
More Information
| Parent CAS No. | 41931-13-9 |
|---|---|
| Chemical Name | 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one |
| SMILES | C1(=O)N(C2=CC=CC(C)=C2)N=CC(Cl)=C1Cl |
| MFCD | MFCD00814448 |
| InChi | InChI=1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3 |
| InChiKey | SYUPLLHVMCLXEM-UHFFFAOYSA-N |
| CID | 779573 |
| Short Description | SOD1 inhibitor |
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