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Wiskostatin
Axon 1804
CAS:
253449-04-6
Purity:
99%
- Soluble in DMSO
- MF: C17H18Br2N2O
- MW: 426.15
Description
Selective, reversible inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) that inhibits Arp2/3 (actin-related protein 2/3) activation; belongs to be an actin inhibitor for actin-dependent cellular functions
More Information
| Parent CAS No. | 253449-04-6 |
|---|---|
| Chemical Name | 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(dimethylamino)propan-2-ol |
| SMILES | N1(CC(CN(C)C)O)C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2 |
| MFCD | MFCD00218393 |
| InChi | InChI=1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3 |
| InChiKey | XUBJEDZHBUPBKL-UHFFFAOYSA-N |
| CID | 2775510 |
| Short Description | N-WASP inhibitor |
References
- G Bompard et al. Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway. BMC Cell Biol. 2008, 9, 42.
- CJ Guerriero and OA Weisz. N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am. J. Physiol. Cell Physiol. 2007, 292(4), C1562-1566.
- AM Wegner et al. N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. J. Biol. Chem. 2008, 283(23), 15912-15920.
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