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TG003
- Parent CAS: 719277-26-6; 300801-52-9(mix E/Z); 1164521-02-1 (E)
- Soluble in DMSO
- MF: C13H15NO2S
- MW: 249.33
Description
Potent and specific inhibitor of Cdc2-like kinase (Clk) family (Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively); a valuable tool to dissect the regulatory mechanisms involving serine/arginine-rich protein phosphorylation signaling pathways in vivo, and potential for the therapeutic manipulation of abnormal splicing
More Information
| Parent CAS No. | 719277-26-6; 300801-52-9(mix E/Z); 1164521-02-1 (E) |
|---|---|
| Chemical Name | (Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one |
| SMILES | C(=C1/N(CC)C2=CC(OC)=CC=C2S/1)C(=O)C |
| MFCD | MFCD00624584 |
| InChi | InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7- |
| InChiKey | BGVLELSCIHASRV-QPEQYQDCSA-N |
| CID | 1893668 |
| Short Description | Clk inhibitor |
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