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NS 3694
Axon 1883
CAS:
426834-38-0
Purity:
99%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C15H10ClF3N2O3
- MW: 358.7
Description
Apoptosis inhibitor; NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase 9; NS2694 exhibits no effect on apoptosome-independent caspase activation and enzymatic activity of caspases
More Information
| Parent CAS No. | 426834-38-0 |
|---|---|
| Chemical Name | 4-chloro-2-(3-(3-(trifluoromethyl)phenyl)ureido)benzoic acid |
| SMILES | C1(NC(=O)NC2C=C(C(F)(F)F)C=CC=2)C(C(O)=O)=CC=C(Cl)C=1 |
| MFCD | MFCD00249000 |
| InChi | InChI=1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24) |
| InChiKey | GNCZTZCPXFDPLI-UHFFFAOYSA-N |
| CID | 10109069 |
| Short Description | Inhibitor of apoptosis |
References
- U Lademann et al. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. Mol. Cell Biol. 2003, 23(21), 7829-7837.
- A. Degterev et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chem. Biol. 2005, 1, 112.
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