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LB 42708
Axon 1794
CAS:
226929-39-1
Purity:
99%
- Soluble in DMSO
- MF: C30H27BrN4O2
- MW: 555.46
Description
Selective and orally available inhibitor of farnesyltransferase (FTase), with IC50 values of 0.8 nM in vitro and 8 nM in cultured cells against p21-ras farnesylation
More Information
| Parent CAS No. | 226929-39-1 |
|---|---|
| Chemical Name | (1-((1-(4-bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone |
| SMILES | C(C1C(C2=C3C(C=CC=C3)=CC=C2)=CN(CC2N(CC3=CC=C(Br)C=C3)C=NC=2)C=1)(N1CCOCC1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C30H27BrN4O2/c31-24-10-8-22(9-11-24)17-35-21-32-16-25(35)18-33-19-28(27-7-3-5-23-4-1-2-6-26(23)27)29(20-33)30(36)34-12-14-37-15-13-34/h1-11,16,19-21H,12-15,17-18H2 |
| InChiKey | GUUIRIMAQGOLHT-UHFFFAOYSA-N |
| CID | 10099206 |
| Short Description | FTase inhibitor |
References
- HJ Na et al. Inhibition of Farnesyltransferase Prevents Collagen-Induced Arthritis by Down-Regulation of Inflammatory Gene Expression through Suppression of p21ras-Dependent NF-κB Activation. J. Immunol. 2004, 173, 1276-1283.
- CK Kim et al. The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting Ras-dependent mitogen-activated protein kinase and PI3K/Akt signal pathways. Mol. Pharmacol. 2010, 78, 142-150.
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