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iBP

Name: iBP
SKU: 4442

- PRC1.1 inhibitor iBP

Axon 4442

CAS: 79790-53-1

Purity: 99%

Soluble in DMSO

MF: C20H16N2O3
MW: 332.35

Description

iBP is potent and selective PRC1.1 inhibitor with an IC50 value of 12.2 μM for inhibition of PCGF1-BCOR. Moreover, iBP administration promotes bone formation in mouse models of bone loss.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

Parent CAS No.	79790-53-1
Chemical Name	3-(Hydroxyimino)-1-(2-(1-naphthyloxy)ethyl)-2-indolinone
Short Description	PRC1.1 inhibitor

iBP PRC1.1 inhibitor PRC1.1 inhibitor iBP CAS 79790-53-1 Axon Medchem Axon 4442 DNA-RNA PRC PRC1.1 Inhibitor Proteins Enzymes Bone remodeling Polycomb repressive complexes H2AK119ub1 BCOR-PCGF1 Supplier Vendor

References

L Xing et al. Targeted disruption of PRC1.1 complex enhances bone remodeling. Nat Commun. 2025 May 8;16(1):4294.

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iBP

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