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PTC 209
Axon 2420
CAS:
315704-66-6
Purity:
99%
- Soluble in DMSO
- MF: C17H13Br2N5OS
- MW: 495.19
Description
PTC 209 is a small-molecule inhibitor of BMI-1, a core regulator of Polycomb repressive complex 1 (PRC1) and cancer stem-cell self-renewal. It suppresses BMI-1 reporter activity and reduces tumor-initiating cell phenotypes in colorectal cancer models.
BMI-1 supports chromatin repression, stemness, proliferation and therapy resistance in several tumor types. PTC 209 is useful for studying PRC1 biology, cancer stem-cell maintenance and pharmacological modulation of self-renewal pathways.
Key Features
- BMI-1/PRC1 pathway inhibitor
- Reported IC50: 0.5 µM in a BMI-1 UTR luciferase reporter assay
- Suppresses self-renewal regulator BMI-1 expression
- Reduces colorectal cancer xenograft and tumor-initiating cell phenotypes in reported studies
Applications
- Cancer stem-cell biology
- Polycomb repressive complex research
- Colorectal cancer pharmacology models
- Stemness and self-renewal pathway assays
More Information
| Parent CAS No. | 315704-66-6 |
|---|---|
| Chemical Name | N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine |
| SMILES | S1C=C(C2N3C(=NC=2C)N=CC=C3)N=C1NC1=C(Br)C=C(OC)C=C1Br |
| MFCD | N.A. |
| InChi | InChI=1S/C17H13Br2N5OS/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19/h3-8H,1-2H3,(H,22,23) |
| InChiKey | XVOOCQSWCCRVDY-UHFFFAOYSA-N |
| CID | 1117196 |
| Short Description | BMI-1 inhibitor |
PTC 209
BMI-1/PRC1 pathway inhibitor
PTC209
BMI-1
polycomb repressive complex 1
PRC1
BMI-1/PRC1 pathway
Inhibitor
Cancer stem-cell biology
Polycomb repressive complex research
Colorectal cancer pharmacology models
Stemness and self-renewal pathway assays
stem cell maintenance
colorectal cancer
cancer biology
enzyme pharmacology
drug discovery
CAS 315704-66-6
Axon Medchem
Axon 2420
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