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MK 677
- Ibutamoren mesylate - L 163191 - MK 0677
Axon 1376
- Parent CAS: 159634-47-6
- Optical Purity: Optically pure
- Soluble in water
- MF: C27H36N4O5S.CH4O3S
- MW: 624.77
Description
Potent and orally active growth hormone (GH) secretagogue; high affinity Ghrelin receptor agonist.
More Information
| Parent CAS No. | 159634-47-6 |
|---|---|
| Chemical Name | 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide; methanesulfonic acid |
| SMILES | C12(C3C(N(S(C)(=O)=O)C1)=CC=CC=3)CCN(C(=O)[C@H](NC(=O)C(C)(C)N)COCC1C=CC=CC=1)CC2.CS(O)(=O)=O |&1:18,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);1H3,(H,2,3,4)/t22-;/m1./s1 |
| InChiKey | DUGMCDWNXXFHDE-VZYDHVRKSA-N |
| CID | 6450830 |
| Short Description | GH secretagogue |
References
- T Jacks et al. MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles. Endocrinology, 1996, 137, 5284-5289.
- MG Murphy et al. MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism. J. Clin. Endocrinol. Meta. 1998, 83, (2), 320-325.
- LA Sorbera et al. Ibutamoren Mesylate. Drugs Fut. 2006, 31(5), 390.
- E Codner et al. Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone–insulin-like growth factor I axis in growth hormone–deficient children. Clin. Pharmacol. Ther. 2001, 70, 91–98.
- Chapman, I.M. et al. Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults.J Clin Endocrinol Metab. 1997, 82(10), 3455-3463.
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