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AZ-GHS-22
Axon 2340
CAS:
1143020-91-0
Purity:
98%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C27H33ClN6O5S2
- MW: 621.17
Description
AZ-GHS-22 is an orally available high-affinity inverse agonist of the ghrelin receptor GHS-R1a with an IC50 value of 0.77 nM. It is characterized by very low CNS exposure, making it useful for studying peripheral ghrelin receptor pharmacology.
Ghrelin receptor signaling regulates appetite, energy balance, gastrointestinal physiology and metabolic control. AZ-GHS-22 supports investigation of GHS-R1a inverse agonism and separation of peripheral metabolic effects from central exposure.
Key Features
- High-affinity GHS-R1a inverse agonist
- IC50: 0.77 nM
- Orally available pharmacological profile
- Very low CNS exposure in reported studies
Applications
- Ghrelin receptor pharmacology
- Metabolic signaling research
- Food-intake pathway studies
- Peripheral versus central GHSR mechanism assays
More Information
| Parent CAS No. | 1143020-91-0 |
|---|---|
| Chemical Name | 2-chloro-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-morpholinobenzamide |
| SMILES | C(C1=CC(N2CCOCC2)=CC=C1Cl)(NC(NC1=NC2=CC=C(S(CCCN3CCN(C)CC3)(=O)=O)C=C2S1)=O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C27H33ClN6O5S2/c1-32-8-10-33(11-9-32)7-2-16-41(37,38)20-4-6-23-24(18-20)40-27(29-23)31-26(36)30-25(35)21-17-19(3-5-22(21)28)34-12-14-39-15-13-34/h3-6,17-18H,2,7-16H2,1H3,(H2,29,30,31,35,36) |
| InChiKey | XWFQFKFKWKWIEW-UHFFFAOYSA-N |
| CID | 57422817 |
| Short Description | GHS-R1a inverse agonist |
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