Bulk Inquiry
Roluperidone
- CYR101 - MT210 - MIN101
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C22H23FN2O2
- MW: 366.43
Description
Roluperidone is a sigma-2 and 5-HT2A receptor antagonist with Ki values of 8.19 nM and 7.53 nM, respectively. Also, Roluperidone shows binding affinity for a1-adrenergic receptors but low or no affinity for muscarinic, cholinergic, and histaminergic receptors.
More Information
| Parent CAS No. | 359625-79-9 |
|---|---|
| Chemical Name | 2-((1-(2-(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one |
| SMILES | C1C=C2C(=O)N(CC3CCN(CC(C4C=CC(F)=CC=4)=O)CC3)CC2=CC=1 |
| MFCD | MFCD28502826 |
| InChi | InChI=1S/C22H23FN2O2/c23-19-7-5-17(6-8-19)21(26)15-24-11-9-16(10-12-24)13-25-14-18-3-1-2-4-20(18)22(25)27/h1-8,16H,9-15H2 |
| InChiKey | RNRYULFRLCBRQS-UHFFFAOYSA-N |
| CID | 9799284 |
| Short Description | Sigma-2/5-HT2A antagonist |
References
- M Davidson et al. Efficacy and Safety of MIN-101: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of a New Drug in Development for the Treatment of Negative Symptoms in Schizophrenia. Am J Psychiatry. 2017 Dec 1;174(12):1195-1202.
- MT Jones et al. Emerging 5-HT receptor antagonists for the treatment of Schizophrenia. Expert Opin Emerg Drugs. 2020 Jun;25(2):189-200.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1102 | Nefazodone hydrochloride |
From $93.50 |
| 1103 | MDL 100151 |
From $121.00 |
| 1104 | MDL 100907 |
From $121.00 |
| 1105 | MDL 100009 |
From $137.50 |
| 1106 | (±)-MDL 105725 |
From $176.00 |
| 1107 | (+)-MDL 105725 |
From $143.00 |
| 1108 | (-)-MDL 105725 |
From Inquiry |
| 1143 | Aripiprazole |
From $82.50 |
| 1144 | Thio-aripiprazole |
From $154.00 |
| 1146 | Clozapine |
From $55.00 |
| 1147 | Isoclozapine |
From $148.50 |
| 1148 | GMC 1-169 |
From $165.00 |
| 1149 | GMC 61-39 |
From Inquiry |
| 1150 | GMC 2-83 |
From $176.00 |
| 1152 | GMC 1-165 |
From $154.00 |
| 1247 | PNU 22394 hydrochloride |
From $99.00 |
| 1272 | PB28 dihydrochloride |
From $104.50 |
| 1439 | Eplivanserin |
From $88.00 |
| 1446 | Ziprasidone hydrochloride |
From $55.00 |
| 1450 | Ketanserin |
From $60.50 |
| 1493 | Iloperidone |
From $93.50 |
| 1499 | Flibanserin |
From $104.50 |
| 1503 | Asenapine maleate |
From $77.00 |
| 2335 | Brexpiprazole dihydrochloride |
From $148.50 |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.