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PB28 dihydrochloride
Axon 1272
- Parent CAS: 172906-90-0
Purity:
99%
- Soluble in water
- MF: C24H38N2O.2HCl
- MW: 443.49
Description
High affinity sigma-2 agonist
More Information
| Parent CAS No. | 172906-90-0 |
|---|---|
| Chemical Name | 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-piperazine dihydrochloride |
| SMILES | C12C(CCCN3CCN(C4CCCCC4)CC3)CCCC=1C(OC)=CC=C2.Cl.Cl |
| MFCD | MFCD06798349 |
| InChi | InChI=1S/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H |
| InChiKey | DSRBJOQIBXACIV-UHFFFAOYSA-N |
| CID | 46861545 |
| Short Description | Sigma-2 agonist |
References
- G Cassano et al. The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells. Cell Calcium 2006, 40(1), 23-28.
- A Azzariti et al. Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer. Mol. Cancer Ther. 2006, 5(7), 1807-1816.
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