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TB5
- Soluble in DMSO
- MF: C15H14BrNOS
- MW: 336.25
Description
Competitive and reversible MAO-B inhibitor (Ki values 1.45 µM and 0.11 µM for hMAO-A and hMAO-B, respectively) capable of crossing the BBB. Valuble tool for development of drugs for neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases.
More Information
| Parent CAS No. | 948841-07-4 |
|---|---|
| Chemical Name | (E)-1-(5-bromothiophen-2-yl)-3-(4-(dimethylamino)phenyl)prop-2-en-1-one |
| SMILES | C(C1SC(Br)=CC=1)(=O)/C=C/C1=CC=C(N(C)C)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H14BrNOS/c1-17(2)12-6-3-11(4-7-12)5-8-13(18)14-9-10-15(16)19-14/h3-10H,1-2H3/b8-5+ |
| InChiKey | PTLDLBSWTKNYCY-VMPITWQZSA-N |
| CID | 101571768 |
| Short Description | MAO-B inhibitor |
References
- B Mathew et al. Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors. ChemMedChem. 2016 Jun 6;11(11):1161-71.
- M Ono et al. Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain. Bioorg Med Chem. 2007 Oct 1;15(19):6388-96.
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