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STING inhibitor C-176
- STING Inhibitor 1
Axon 2923
CAS:
314054-00-7
Purity:
99%
- Soluble in DMSO
- MF: C11H7IN2O4
- MW: 358.09
Description
C-176 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. Moreover, C-176 attenuates pathological features of autoinflammatory disease in mice. Also, C-176 is an activator of CHOP expression and exhibits antitumor activity in TNBC cells.
More Information
| Parent CAS No. | 314054-00-7 |
|---|---|
| Chemical Name | N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide |
| SMILES | C1=C([N+]([O-])=O)OC(C(=O)NC2C=CC(I)=CC=2)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C11H7IN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15) |
| InChiKey | JBIKQXOZLBLMKI-UHFFFAOYSA-N |
| CID | 1103958 |
| Short Description | STING antagonist |
References
- H Duan et al. Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression. Bioorg Med Chem. 2015 Aug 1;23(15):4514-21.
- SM Haag et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.
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