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Ivabradine hydrochloride
- (+)-S16257
Axon 3495
- Parent CAS: 155974-00-8
- Optical Purity: Optically pure
- Soluble in water, DMSO and EtOH
- MF: C27H36N2O5.HCl
- MW: 505.05
Description
Ivabradine hydrochloride is a selective sinus node I(f) channel inhibitor. Ivabradine is the first specific heart rate-lowering agent that has completed clinical development for stable angina pectoris. It is selective for the I(f) current, lowering heart rate at concentrations that do not affect other cardiac ionic currents.
More Information
| Parent CAS No. | 155974-00-8 |
|---|---|
| Chemical Name | (S)-3-(3-(((4,5-Dimethoxy-1,2-dihydrocyclobutabenzen-1-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride |
| SMILES | C1(OC)C=C2CCN(CCCN(C)C[C@@H]3C4C=C(OC)C(OC)=CC=4C3)C(=O)CC2=CC=1OC.Cl |&1:14,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1 |
| InChiKey | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
| CID | 3045381 |
| Short Description | I(f) channel inhibitor |
References
- C Thollon et al. Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br J Pharmacol. 1994 May;112(1):37-42.
- M Novella Romanelli et al. HCN Channels Modulators: The Need for Selectivity. Curr Top Med Chem. 2016;16(16):1764-91.
- S Sulfi et al. Ivabradine -- the first selective sinus node I(f) channel inhibitor in the treatment of stable angina. Int J Clin Pract. 2006 Feb;60(2):222-8.
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