Bulk Inquiry
AZD3463
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C24H25ClN6O
- MW: 448.95
Description
More Information
| Parent CAS No. | 1356962-20-3 |
|---|---|
| Chemical Name | N-(4-(4-aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine |
| SMILES | C1(NC2=CC=C(N3CCC(N)CC3)C=C2OC)=NC=C(Cl)C(C2C3=C(NC=2)C=CC=C3)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H25ClN6O/c1-32-22-12-16(31-10-8-15(26)9-11-31)6-7-21(22)29-24-28-14-19(25)23(30-24)18-13-27-20-5-3-2-4-17(18)20/h2-7,12-15,27H,8-11,26H2,1H3,(H,28,29,30) |
| InChiKey | GCYIGMXOIWJGBU-UHFFFAOYSA-N |
| CID | 56599293 |
| Short Description | ALK inhibitor |
References
- Y Wang et al. Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis. Sci Rep. 2016 Jan 20;6:19423.
- Concurrent roles for IGF1R and EGFR in driving acquired resistance to crizotinib and ability to overcome with a combination of the ALK/IGF1R inhibitor AZD3463 and Iressa. Abstr. 4465 presented by L Drew et al. AACR Annual Meeting 2013 Washington DC USA.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1416 | NVP-TAE684 |
From $55.00 |
| 1660 | Crizotinib |
From $88.00 |
| 1884 | Alectinib |
From $77.00 |
| 2005 | ASP 3026 |
From $88.00 |
| 2224 | LDK 378 |
From $104.50 |
| 2267 | GSK 1838705A |
From $121.00 |
| 2294 | KRCA 0008 |
From $104.50 |
| 2600 | PF 06463922 |
From $115.50 |
| 2978 | Brigatinib |
From $88.00 |
| 3931 | CEP-28122 |
From Inquiry |
| 3973 | XL-228 |
From Inquiry |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.