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STM2457
Axon 3587
CAS:
2499663-01-1
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C25H28N6O2
- MW: 444.53
Description
STM2457 is a first-in-class, highly potent and selective catalytic inhibitor of the m6A writer METTL3 (IC50 of 16.9 nM for METTL3/METTL14 catalytic activity).
More Information
| Parent CAS No. | 2499663-01-1 |
|---|---|
| Chemical Name | N-((6-((Cyclohexylmethylamino)methyl)imidazo[1,2-a]pyridin-2-yl)methyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide |
| SMILES | C1=CN2C(=O)C=C(C(=O)NCC3=CN4C=C(CNCC5CCCCC5)C=CC4=N3)N=C2C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C25H28N6O2/c32-24-12-21(29-23-8-4-5-11-31(23)24)25(33)27-15-20-17-30-16-19(9-10-22(30)28-20)14-26-13-18-6-2-1-3-7-18/h4-5,8-12,16-18,26H,1-3,6-7,13-15H2,(H,27,33) |
| InChiKey | OBERVORNENYOLE-UHFFFAOYSA-N |
| CID | 155167581 |
| Short Description | METTL3 inhibitor |
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