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STC-15

Name: STC-15
SKU: 4401

Axon 4401

CAS: 2648257-56-9

Purity: 99%

Soluble in 0.1N HCl(aq) and DMSO

MF: C24H25N5O2
MW: 415.49

Description

STC-15 is an orally bioavailable RNA methyltransferase METTL3 inhibitor which inhibits tumour growth through activation of anti-cancer immune responses associated with increased interferon signalling, and synergises with T cell checkpoint blockade.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

Methyltransferases

Parent CAS No.	2648257-56-9
Chemical Name	N-((2-(((Cyclobutylmethyl)amino)methyl)-6-indolyl)methyl)-4-oxo-1,4a-diaza-4H-naphthalene-2-carboxamide
Short Description	METTL3 inhibitor

STC-15 METTL3 inhibitor STC15 STC 15 CAS 2648257-56-9 Axon Medchem Axon 4401 DNA-RNA Inhibitor Enzymes Acute myeloid leukemia AML Supplier Vendor

References

Y Ofir-Rosenfeld et al. STC-15, an oral small molecule inhibitor of the RNA methyltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses associated with increased interferon signalling, and synergises with T cell checkpoint blockade. European Journal of Cancer, 2022, 174: S123.

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STC-15

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