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SN-011
- Soluble in DMSO and EtOH
- MF: C25H19FN2O4S
- MW: 462.49
Description
SN-011 is a potent and selective mouse and human STING inhibitor (IC50 value of 76 nM) that blocked induction of type I IFNs and proinflammatory cytokines in response to cytosolic DNA. SN-011 binds with higher affinity to the cyclic dinucleotide (CDN)-binding pocket of STING than endogenous 2'3'-cGAMP.
More Information
| Parent CAS No. | 2249435-90-1 |
|---|---|
| Chemical Name | N-(3-(4-Fluorophenylsulfonylamino)-4-hydroxyphenyl)-4-biphenylcarboxamide |
| SMILES | C1=C(NC(=O)C2=CC=C(C3=CC=CC=C3)C=C2)C=CC(O)=C1NS(=O)(=O)C1=CC=C(F)C=C1 |
| InChi | InChI=1S/C25H19FN2O4S/c26-20-10-13-22(14-11-20)33(31,32)28-23-16-21(12-15-24(23)29)27-25(30)19-8-6-18(7-9-19)17-4-2-1-3-5-17/h1-16,28-29H,(H,27,30) |
| InChiKey | GPXQUPCJIJBXHJ-UHFFFAOYSA-N |
| CID | 138005721 |
| Short Description | STING inhibitor |
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