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TH 5487
- Soluble in DMSO
- MF: C19H18BrIN4O2
- MW: 541.18
Description
TH 5487 is a potent and selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with an IC50 of 342 nM. TH 5487 inhibited DNA repair and modified OGG1 chromatin dynamics, which resulted in the inhibition of proinflammatory pathway genes. Furthermore, TH 5487 was well tolerated by mice and suppressed lipopolysaccharide- and tumor necrosis factor–α–mediated neutrophilic inflammation in the lungs.
More Information
| Parent CAS No. | 2304947-71-3 |
|---|---|
| Chemical Name | 4-(4-Bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide |
| SMILES | C1N(C(NC2C=CC(I)=CC=2)=O)CCC(N2C3C=CC=C(Br)C=3NC2=O)C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H18BrIN4O2/c20-15-2-1-3-16-17(15)23-19(27)25(16)14-8-10-24(11-9-14)18(26)22-13-6-4-12(21)5-7-13/h1-7,14H,8-11H2,(H,22,26)(H,23,27) |
| InChiKey | FZLKVWWPFOLPKF-UHFFFAOYSA-N |
| CID | 137321164 |
| Short Description | OGG1 inhibitor |
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