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5 mg

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Pyrone-211

Name: Pyrone-211
SKU: 4285

Axon 4285

CAS: 90632-45-4

Purity: 99%

Soluble in DMSO and EtOH

MF: C12H18O3
MW: 210.27

Description

Pyrone-211 is a potent GPR84 agonist and AKR1C3 inhibitor.

More Information

Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

Dehydrogenase (17β-hydroxysteroid, type 5)

Parent CAS No. 90632-45-4

Chemical Name 6-Heptyl-4-hydroxy-2H-pyran-2-one

SMILES C1(O)=CC(=O)OC(CCCCCCC)=C1

MFCD N.A.

InChi InChI=1S/C12H18O3/c1-2-3-4-5-6-7-11-8-10(13)9-12(14)15-11/h8-9,13H,2-7H2,1H3

InChiKey DYBQTVWGTMHKLN-UHFFFAOYSA-N

CID 54678950

Short Description GPR84 agonist; AKR1C3 inhibitor

Pyrone-211 GPR84 agonist; AKR1C3 inhibitor Pyrone211 Pyrone 211 CAS 90632-45-4 Axon Medchem Axon 4285 Androstenedione Dehydroepiandrosterone FFA Dehydrogenase (17β-hydroxysteroid type 5) GPR84 Agonist Inhibitor Enzymes Receptors Altered human aldo-keto reductase family 1 member C3 Ferroptosis Oxidative stress Polyamine (immune) metabolic pathway Supplier Vendor

References

N Dudkina et al. Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Cell Chem Biol. 2024 Aug 9:S2451-9456(24)00313-1.

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Pyrone-211

Description

More Information

References

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Other Categories

Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research

Axon Ligands™ for Epigenetic Research

Parent CAS No.	90632-45-4
Chemical Name	6-Heptyl-4-hydroxy-2H-pyran-2-one
SMILES	C1(O)=CC(=O)OC(CCCCCCC)=C1
MFCD	N.A.
InChi	InChI=1S/C12H18O3/c1-2-3-4-5-6-7-11-8-10(13)9-12(14)15-11/h8-9,13H,2-7H2,1H3
InChiKey	DYBQTVWGTMHKLN-UHFFFAOYSA-N
CID	54678950
Short Description	GPR84 agonist; AKR1C3 inhibitor

AXON ID	NAME	DESCRIPTION	FROM PRICE
2616	ZQ-16	Potent and selective GPR84 agonist that induces phosphorylation of ERK1/2	From $104.50
2787	ASP 9521	Inhibitor of 17 β–hydroxysteroid dehydrogenase type 5	From $82.50
4396	OX04528	Highly potent, G-Protein pathway biased, selective, and orally bioavailable GPR84 agonist	From $137.50