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ASP 9521
Axon 2787
CAS:
1126084-37-4
Purity:
99%
- Soluble in DMSO
- MF: C19H26N2O3
- MW: 330.42
Description
ASP 9521 is a novel, selective, orally bioavailable inhibitor of 17β–hydroxysteroid dehydrogenase type 5 (17β-HSD5; AKR1C3) with IC50 values of 11 and 49 nM in recombinant human and cynomolgus monkey AKR1C3, respectively.
More Information
| Parent CAS No. | 1126084-37-4 |
|---|---|
| Chemical Name | (4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl)(5-methoxy-1H-indol-2-yl)methanone |
| SMILES | C1CC(CC(O)(C)C)CCN1C(C1NC2C=CC(OC)=CC=2C=1)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C19H26N2O3/c1-19(2,23)12-13-6-8-21(9-7-13)18(22)17-11-14-10-15(24-3)4-5-16(14)20-17/h4-5,10-11,13,20,23H,6-9,12H2,1-3H3 |
| InChiKey | OXSCPDKUZWPWFR-UHFFFAOYSA-N |
| CID | 25210792 |
| Short Description | 17β-HSD5 inhibitor |
References
- A Kikuchi et al. In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). Invest New Drugs. 2014 Oct;32(5):860-70.
- Y Loriot et al. Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study. Invest New Drugs. 2014 Oct;32(5):995-1004.
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