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S-Propargyl-Cysteine
- SPRC - ZYZ-802
Axon 2666
CAS:
3262-64-4
- Optical Purity: Optically pure
- Soluble in water
- MF: C6H9NO2S
- MW: 159.21
Description
S-Propargyl-cysteine (SPRC), a substrate of cystathionine γ-lyase (CSE), is a water-soluble modulator of endogenous hydrogen disulfide (H2S). SPRC is a potential agent for the treatment of Alzheimer’s disease (TNF signalling, the NF-κB pathway and the ERK1/2 pathway), anemia of inflammation (IL-6/JAK2/STAT3 pathway), ischemic heart disease (H2S/VEGFR2/STAT3 pathway) and myocardial infarction.
More Information
| Parent CAS No. | 3262-64-4 |
|---|---|
| Chemical Name | (R)-2-Amino-3-(prop-2-ynylthio)propanoic acid |
| SMILES | C(C#C)SC[C@@H](C(O)=O)N |&1:5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C6H9NO2S/c1-2-3-10-4-5(7)6(8)9/h1,5H,3-4,7H2,(H,8,9)/t5-/m0/s1 |
| InChiKey | JAKVEOCMEMGHGB-YFKPBYRVSA-N |
| CID | 22789047 |
| Short Description | H2S donor |
References
- Q Wang et al. S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway. J Cardiovasc Pharmacol. 2009 Aug;54(2):139-46.
- QH Gong et al. S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-κB pathway in rats. Brain Behav Immun. 2011 Jan;25(1):110-9.
- QH Gong et al. S-Propargyl-Cysteine (ZYZ-802), a Sulphur-Containing Amino Acid, Attenuates Beta-Amyloid-Induced Cognitive Deficits and Pro-Inflammatory Response: Involvement of ERK1/2 and NF-κB Pathway in Rats. Amino Acids. 2011 Feb;40(2):601-10.
- J Kan et al. S-propargyl-cysteine, a novel water-soluble modulator of endogenous hydrogen sulfide, promotes angiogenesis through activation of signal transducer and activator of transcription 3. Antioxid Redox Signal. 2014 May 20;20(15):2303-16.
- M Wang et al. S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway. PLoS One. 2016 Sep 20;11(9):e0163289.
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