Cystathionine γ-lyase (EC 4.4.1.1) (CSE) is a pyroxidal-5’-phosphate-dependent enzyme, which uses L-cysteine as its principal substrate for the enzymatic production of hydrogen sulfide (H2S). CSE is abundant in heart, liver, kidney, and vascular smooth muscle and is the most relevant H2S-producing enzyme in the cardiovascular system. A number of studies have demonstrated that the CSE/H2S pathway may be involved in a multitude of pathophysiologic processes of cardiovascular disease, such as myocardial ischemia, atherosclerosis and hypertension.[1]