List of publications using LDN 193189 (Axon 1509) purchased from Axon Medchem
(Total 68 publication citations listed; updated MAY-2019)
2019
Eddowes, L. A., Al-Hourani, K., Ramamurthy, N., Frankish, J., Baddock, H. T., Sandor, C., ... & Boninsegna, S. (2019). Antiviral activity of bone morphogenetic proteins and activins. Nature microbiology, 4(2), 339.
https://www.nature.com/articles/s41564-018-0301-9
Rostovskaya, M., Stirparo, G. G., & Smith, A. (2019). Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development, 146(7), dev172916.
2018
Chal, J., Al Tanoury, Z., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., ... & Sumara, O. (2018). Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Development, 145
http://dev.biologists.org/content/145/6/dev157339
(*CHIR99021 and LDN-193189 from Axon MedChem)
Mae, S. I., Ryosaka, M., Toyoda, T., Matsuse, K., Oshima, Y., Tsujimoto, H., ... & Osafune, K. (2018). Generation of branching ureteric bud tissues from human pluripotent stem cells. Biochemical and biophysical research communications, 495(1), 954-961.
https://www.sciencedirect.com/science/article/pii/S0006291X17322842
SHOJI, Masanobu. Method for producing dopaminergic neurons. U.S. Patent Application No 10/017,734, 2018.
https://patents.google.com/patent/US10017734B2/en
*CHIR99021, LDN193189, SB431542, SHH and purmorphamine
Kraniak, J. M., Chalasani, A., Wallace, M. R., & Mattingly, R. R. (2017). development of 3d culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening. Experimental neurology.
https://www.sciencedirect.com/science/article/pii/S0014488617302728
Astrologo, L., Zoni, E., Karkampouna, S., Gray, P. C., Klima, I., Grosjean, J., ... & Thalmann, G. N. (2017). ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models. Frontiers in cell and developmental biology, 5, 104.
https://www.frontiersin.org/articles/10.3389/fcell.2017.00104/full
https://patents.google.com/patent/US20170275593A1/en
* LDN193189, Thiazovivin, CGP77675, DPAT, DBZ, Ly2886721, BIRB796, RU-SKI43 from Axon Medchem
Spottiswoode, N., Armitage, A. E., Williams, A. R., Fyfe, A. J., Biswas, S., Hodgson, S. H., ... & Drakesmith, H. (2017). Role of activins in hepcidin regulation during malaria. Infection and immunity, 85(12), e00191-17.
Zeng, H., Ortiz, A., Shen, P. F., Cheng, C. J., Lee, Y. C., Yu, G., ... & Lin, S. H. (2017). Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway. Oncotarget, 8(6), 10145.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354648/
Chal, J., Al Tanoury, Z., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., ... & Garnier, J. M. (2017). Recapitulating Early Development Of Mouse Musculoskeletal Precursors Of The Paraxial Mesoderm In Vitro. bioRxiv, 140574.
2016
Matsuno, K., Mae, S. I., Okada, C., Nakamura, M., Watanabe, A., Toyoda, T., ... & Osafune, K. (2016). Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells. Differentiation, 92(5), 281-290.
http://www.sciencedirect.com/science/article/pii/S0301468116300238
(CHIR99021 and LDN193189 from Axon Medchem)
Song, W., Tung, C. K., Lu, Y. C., Pardo, Y., Wu, M., Das, M., ... & Ma, M. (2016). Dynamic self-organization of microwell-aggregated cellular mixtures. Soft matter, 12(26), 5739-5746.
http://pubs.rsc.org/-/content/articlehtml/2016/sm/c6sm00456c
Heesen, L., Peitz, M., Torres-Benito, L., Hölker, I., Hupperich, K., Dobrindt, K., ... & Hosseini-Barkooie, S. M. (2016). Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals. Cellular and molecular life sciences, 73(10), 2089-2104.
https://link.springer.com/article/10.1007/s00018-015-2084-y
Pfisterer, U., Ek, F., Lang, S., Soneji, S., Olsson, R., & Parmar, M. (2016). Small molecules increase direct neural conversion of human fibroblasts. Scientific reports, 6, 38290.
https://www.nature.com/articles/srep38290?WT.feed_name=subjects_stem-cell-research
(CHIR99021 and LDN193189 from Axon Medchem)
Jungverdorben, J., Evert, B. O., Peitz, M., Borghese, L., & Brüstle, O. Beate Roese-Koerner, Laura Stappert, Thomas Berger, Nils Christian Braun, Monika Veltel. (2016) Reciprocal Regulation between Bifunctional miR-9/9* and its Transcriptional
Modulator Notch in Human Neural Stem Cell Self-Renewal and
Differentiation. Stem Cell Reports. 2016, 7, 207.
http://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(16)30100-X
Osafune, Kenji, Takafumi Toyohara, and Yukiko Yamagishi. "METHOD FOR PRODUCING RENAL PROGENITOR CELLS, AND DRUG COMPRISING THE SAME." U.S. Patent No. 20,160,137,985. 19 May 2016.
http://www.freepatentsonline.com/y2016/0137985.html
*LDN193189 and Dorsomorphine
Matsuno, Kunihiko, et al. "Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells." Differentiation (2016).
http://www.sciencedirect.com/science/article/pii/S0301468116300238
http://www.freepatentsonline.com/y2016/0137985.html
http://www.sciencedirect.com/science/article/pii/S0945053X16300099
http://www.sciencedirect.com/science/article/pii/S0012160616300112
http://joe.endocrinology-journals.org/content/early/2016/03/30/JOE-16-0053.abstract
http://www.jci.org/articles/view/85526
LSB: LDN193189 and SB431542 from Axon Medchem
https://openaccess.leidenuniv.nl/handle/1887/38502
Lee, Yu-Chen, et al. "Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment." Molecular & Cellular Proteomics 14.3 (2015): 471-483.
https://www.mcponline.org/content/14/3/471.full
*SD208, GW788388 and LDN193189 from Axon Medchem
http://www.nature.com/nprot/journal/v10/n10/full/nprot.2015.097.html
http://www.nature.com/ki/journal/v87/n1/abs/ki2014223a.html
http://www.nature.com/ncomms/2015/150724/ncomms8776/full/ncomms8776.html
https://www.google.com/patents/US9095579
http://jbx.sagepub.com/content/20/9/1074.full
*CHIR99021, LDN193189, WP1066, and S31-201 from Axon Medchem
https://www.jneurosci.org/content/35/39/13385.full
Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.
Lavoz, C., Alique, M., Rodrigues‐Diez, R., Pato, J., Keri, G., Mezzano, S., Egido, J., & Ruiz‐Ortega, M.
J. Pathol. 2015, online 19 MAY 2015. DOI: 10.1002/path.4537
Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling.
Watmuff, B., Hartley, B. J., Hunt, C. P., Fabb, S. A., Pouton, C. W., & Haynes, J. M.
Front Cell Neurosci. 2015, 9, 104. doi: 10.3389/fncel.2015.00104
Dullard/Ctdnep1 Regulates Endochondral Ossification via Suppression of TGF‐β Signaling.
Hayata, T., Asashima, M., Nishinakamura, R., & Noda, M.
J. Bone Mineral Res. 2015, 30(2), 318-329. DOI: 10.1002/jbmr.2343
2014
In vitro Differentiation of Pluripotent Stem Cells towards either Forebrain GABAergic or Midbrain Dopaminergic Neurons. Neural Stem Cell Assays, 91.
Hartley, B. J., Watmuff, B., Hunt, C. P.J., Haynes, J. M. and Pouton, C. W.
Neural Stem Cell Assays, 2014, 91 (eds N. Kaur and M. C. Vemuri), John Wiley & Sons, Inc, Hoboken, NJ, USA. doi: 10.1002/9781118308295.ch10
* SB431542 (Axon 1661), LDN193189 (Axon 1509) and DAPT (Axon 1484) were procured from Axon Medchem.
** Other two drugs used in this paper, CHIR99021 (Axon 1386) and Purmorphamine (Axon 1690), are also available at Axon Medchem.
ISOLATED NAIVE PLURIPOTENT STEM CELLS AND METHODS OF GENERATING SAME.
Hanna, Y., Novershtern, N., & Rais, Y. (2014). U.S. Patent No. 20,140,315,301. Washington, DC: U.S.
* about 30 inhibitors has been cited from Axon Medchem
U.S. Patent No. 20,130,203,793.