List of publications using LDN 193189 (Axon 1509) purchased from Axon Medchem

(Total 112 publication citations listed; updated up to July 2023)

Ito, R., Kimura, A., Hirose, Y., Hatano, Y., Mima, A., Mae, S. I., ... & Osafune, K. (2023). Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model. Scientific Reports13(1), 8659.

Naito, Y., Sakamoto, S., Kojima, T., Homma, M., Tanaka, M., & Matsui, H. (2023). Novel beta-Glucocerebrosidase Chaperone Compounds Identified from Cell-based Screening Reduce Pathologically Accumulated Glucosylsphingosine in iPS-derived Neuronal Cells. SLAS Discovery.
* CHIR99021 and LDN193189 from Axon Medchem

Mae, S. I., Hattanda, F., Morita, H., Nozaki, A., Katagiri, N., Ogawa, H., ... & Osafune, K. (2023). Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD. Cell Reports.
* LDN193189 and tolvaptan from Axon Medchem

Bricker, R. L., Bhaskar, U., Titone, R., Carless, M. A., & Barberi, T. (2022). A molecular analysis of neural olfactory placode differentiation in human pluripotent stem cells. Stem Cells and Development31(17-18), 507-520.

Ryosaka, M., Mae, S. I., & Osafune, K. (2022). Protocol for the generation and expansion of human iPS cell-derived ureteric bud organoids. STAR protocols3(3), 101484.

Rousset, F., Schilardi, G., Sgroi, S., Nacher-Soler, G., Sipione, R., Kleinlogel, S., & Senn, P. (2022). WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro. Cells11(15), 2431.
* CHIR99021, SB431542 and LDN193189 from Axon Medchem

Yamamoto, T., Sato, Y., Yasuda, S., Shikamura, M., Tamura, T., Takenaka, C., ... & Kawamata, S. (2022). Correlation Between Genetic Abnormalities in Induced Pluripotent Stem Cell-Derivatives and Abnormal Tissue Formation in Tumorigenicity Tests. Stem Cells Translational Medicine11(5), 527-538.

Lesage, R., Ferrao Blanco, M. N., Narcisi, R., Welting, T., van Osch, G. J., & Geris, L. (2022). An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis. Bmc Biology20(1), 253.
*Foskolin, PD0325901, PD161570, LDN193189, LY294002 from Axon Medchem

Röderer, P., Belu, A., Heidrich, L., Siobal, M., Isensee, J., Prolingheuer, J., ... & Hucho, T. (2022). Emergence of nociceptive functionality and opioid signaling in human iPSC-derived sensory neurons. Pain, 10-1097.
* LDN193189 and DAPT from Axon Medchem

Rostovskaya, M., Andrews, S., Reik, W., & Rugg-Gunn, P. J. (2022). Amniogenesis occurs in two independent waves in primates. Cell Stem Cell29(5), 744-759.

Glinkina, K., Groenewoud, A., Teunisse, A. F., Snaar-Jagalska, B. E., & Jochemsen, A. G. (2022). Novel treatments of uveal melanoma identified with a synthetic lethal CRISPR/Cas9 screen. Cancers14(13), 3186.

Rodriguez-Gatica, J. E., Iefremova, V., Sokhranyaeva, L., Yeung, S. W. C. A., Breitkreuz, Y., Brüstle, O., ... & Kubitscheck, U. (2022). Imaging three-dimensional brain organoid architecture from meso-to nanoscale across development. Development149(20), dev200439.

Glinkina, K., Groenewoud, A., Teunisse, A. F. A. S., Snaar-Jagalska, B. E., & Jochemsen, A. G. (2022). Novel treatments of uveal melanoma identified with a synthetic lethal CRISPR/Cas9 screen. Cancers14(13). doi:10.3390/cancers14133186

Preisler, L., Habib, A., Shapira, G., Kuznitsov-Yanovsky, L., Mayshar, Y., Carmel-Gross, I., ... & Ben-Yosef, D. (2021). Heterozygous APC germline mutations impart predisposition to colorectal cancer. Scientific reports11(1), 5113.
* CHIR99021, LDN193189 and Y27632 from Axon Medchem

Tong, Z., Kwak, E., Aguiar, A., Peng, B., Pouton, C. W., Voelcker, N. H., & Haynes, J. M. (2021). Compartmentalized microfluidic chambers enable long-term maintenance and communication between human pluripotent stem cell-derived forebrain and midbrain neurons. Lab on a Chip21(20), 4016-4030.

Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., ... & Hanna, J. H. (2021). Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell stem cell28(9), 1549-1565.
* LDN193189, CHIR99021, PD0325901, IWR1, BIRB0796, GO6983, Y27632, CGP77675, RIN1, A 83-01, SB590895, BIX02189, RU-SKI43 and BIX01294 from Axon Medchem

Hoffmann, A., de Souza, L. V., Seifert, M., von Raffay, L., Haschka, D., Grubwieser, P., ... & Weiss, G. (2021). Pharmacological targeting of BMP6-SMAD mediated hepcidin expression does not improve the outcome of systemic infections with intra-or extracellular gram-negative bacteria in mice. Frontiers in Cellular and Infection Microbiology11, 705087.

Fukusumi, H., Togo, K., Sumida, M., Nakamori, M., Obika, S., Baba, K., ... & Kanemura, Y. (2021). Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication. FEBS Open bio11(2), 354-366.

Akiyama, T., Sato, S., Ko, S. B., Sano, O., Sato, S., Saito, M., ... & Iwata, H. (2021). Synthetic mRNA-based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease-induced pluripotent stem cells. Stem Cells Translational Medicine10(4), 572-581.

Togo, K., Fukusumi, H., Shofuda, T., Ohnishi, H., Yamazaki, H., Hayashi, M. K., ... & Kanemura, Y. (2021). Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro. Molecular Brain14(1), 1-17.

Bakker, W., Dingenouts, C. K., Lodder, K., Wiesmeijer, K. C., de Jong, A., Kurakula, K., ... & Goumans, M. J. T. (2021). BMP receptor inhibition enhances tissue repair in endoglin heterozygous mice. International journal of molecular sciences22(4), 2010.

Duan, X., Tang, X., Nair, M. S., Zhang, T., Qiu, Y., Zhang, W., ... & Chen, S. (2021). An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell Reports37(6).

Liu, L., Zhang, C., Wang, J., Liu, X., Qu, H., Zhang, G., ... & Zhang, J. (2021). A high level of lncFGD5-AS1 inhibits epithelial-to-Mesenchymal transition by regulating the miR-196a-5p/SMAD6/BMP axis in gastric Cancer. BMC cancer21(1), 1-14.

Lesage, R., Ferrao Blanco, M. N., Narcisi, R., Welting, T., van Osch, G. J., & Geris, L. (2021). An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis. bioRxiv, 2021-09.
* LDN193189, Fosklin, PD0325901, LY294002 and PD161570 from Axon Medchem

Repudi, S., Steinberg, D. J., Elazar, N., Breton, V. L., Aquilino, M. S., Saleem, A., ... & Aqeilan, R. I. (2021). Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects. Brain144(10), 3061-3077.

Bakker, W., Dingenouts, C. K. E., Lodder, K., Wiesmeijer, K. C., Jong, A. de, Kurakula, K., ... Goumans, M. J. T. H. (2021). BMP receptor inhibition enhances tissue repair in endoglin heterozygous mice. International Journal Of Molecular Sciences22(4). doi:10.3390/ijms22042010

Steinberg, D. J., Repudi, S., Saleem, A., Kustanovich, I., Viukov, S., Abudiab, B., ... & Aqeilan, R. I. (2021). Modeling genetic epileptic encephalopathies using brain organoids. EMBO Molecular Medicine13(8), e13610.
* CHIR99021, A 83-01 and LDN193189 from Axon Medchem

Kinoshita, M., Barber, M., Mansfield, W., Cui, Y., Spindlow, D., Stirparo, G. G., ... & Smith, A. (2021). Capture of mouse and human stem cells with features of formative pluripotency. Cell stem cell28(3), 453-471.

Norapat, N. (2021). Investigation of Induced-Lung Progenitor Cell Differentiation Methods.

Sedlmeier, G., Al‐Rawi, V., Buchert, J., Yserentant, K., Rothley, M., Steshina, A., ... & Sleeman, J. P. (2021). Id1 and Id3 Are Regulated Through Matrix‐Assisted Autocrine BMP Signaling and Represent Therapeutic Targets in Melanoma. Advanced Therapeutics4(2), 2000065.

Kwak, E. (2021). Evaluating the effect of Amyloid β on inflammatory response and synaptic health of forebrain neurons derived from human embryonic stem cells (Doctoral dissertation, Monash University).

Uchimura, K., Wu, H., Yoshimura, Y., & Humphreys, B. D. (2020). Human pluripotent stem cell-derived kidney organoids with improved collecting duct maturation and injury modeling. Cell reports33(11).

Mae, S. I., Ryosaka, M., Sakamoto, S., Matsuse, K., Nozaki, A., Igami, M., ... & Osafune, K. (2020). Expansion of human iPSC-derived ureteric bud organoids with repeated branching potential. Cell reports32(4).

Kidwai, F., Mui, B. W., Arora, D., Iqbal, K., Hockaday, M., Castro Diaz, L. F., ... & Robey, P. G. (2020). Lineage-specific differentiation of osteogenic progenitors from pluripotent stem cells reveals the FGF1-RUNX2 association in neural crest-derived osteoprogenitors. Stem Cells38(9), 1107-1123.

Zorzan, I., Pellegrini, M., Arboit, M., Incarnato, D., Maldotti, M., Forcato, M., ... & Martello, G. (2020). The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs. Nature Communications11(1), 2364.
* Y27632, SB431542 and LDN193189 from Axon Medchem

Bayerl, J., Ayyash, M., Shani, T., Manor, Y., Gafni, O., Kalma, Y., ... & Hanna, J. H. (2020). Tripartite inhibition of SRC-WNT-PKC signalling consolidates human naïve pluripotency. bioRxiv, 2020-05.
* LDN193189, CHIR99021, PD0325901, XAV939, Y27632, CGP77675, GO6983, IWR1, BIRB796, A8301, DBZ, SB590895, BIX01294 and BIX02189 from Axon Medchem

Malaguti, M., Migueles, R. P., Blin, G., Lin, C. Y., & Lowell, S. (2019). Id1 stabilizes epiblast identity by sensing delays in nodal activation and adjusting the timing of differentiation. Developmental Cell50(4), 462-477.
* CHIR99021, PD0325901 and LDN193189 from Axon Medchem

Rhee, H. J., Shaib, A. H., Rehbach, K., Lee, C., Seif, P., Thomas, C., ... & Rhee, J. S. (2019). An autaptic culture system for standardized analyses of iPSC-derived human neurons. Cell reports27(7), 2212-2228.
* SB431542 and LDN193189 from Axon Medchem

Dingenouts, C. K., Bakker1&, W., Lodder, K., Wiesmeijer, K. C., Moerkamp, A. T., Mager, H. J. J., ... & Goumans, M. J. (2019). BMP receptor inhibition enhances tissue repair in endoglin heterozygous mice. Influencing the homing and differentiation of MNCs in hereditary hemorrhagic telangiectasia, 69.

Cosset, E., Locatelli, M., Marteyn, A., Lescuyer, P., Antonia, F. D., Mor, F. M., ... & Tieng, V. (2019). Human neural organoids for studying brain cancer and neurodegenerative diseases. JoVE (Journal of Visualized Experiments), (148), e59682.
* CHIR99021 and LDN193189 from Axon Medchem

Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2019). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nature cell biology21(2), 275-286.
* CHIR99021, PD0325901, GO6983, SB431542 and LDN193189 from Axon Medchem

Meijer, M., Rehbach, K., Brunner, J. W., Classen, J. A., Lammertse, H. C., van Linge, L. A., ... & Verhage, M. (2019). A single-cell model for synaptic transmission and plasticity in human iPSC-derived neurons. 
Cell reports27(7), 2199-2211.
* SB431542 and LDN193189 from Axon Medchem

Lombardo, V. A., Heise, M., Moghtadaei, M., Bornhorst, D., Männer, J., & Abdelilah-Seyfried, S. (2019). Morphogenetic control of zebrafish cardiac looping by Bmp signaling. Development146(22), dev180091.

Rostovskaya, M., Stirparo, G. G., & Smith, A. (2019). Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. 
Development146(7), dev172916.

Eddowes, L. A., Al-Hourani, K., Ramamurthy, N., Frankish, J., Baddock, H. T., Sandor, C., ... & Boninsegna, S. (2019). Antiviral activity of bone morphogenetic proteins and activins. Nature microbiology, 4(2), 339.

Mae, S. I., Ryosaka, M., & Osafune, K. (2019). Protocol to Generate Ureteric Bud Structures from Human iPS Cells. In Kidney Organogenesis (pp. 117-123). Humana Press, New York, NY.

Rostovskaya, M., Stirparo, G. G., & Smith, A. (2019). Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development, 146(7), dev172916.

OSAFUNE, Kenji; TOYODA, Taro; KIMURA, Azuma. Method for producing pancreatic bud cells. U.S. Patent Application No 15/760,523, 2018.
*LDN193189 and CHIR99021 from Axon Medchem

Kraniak, J. M., Chalasani, A., Wallace, M. R., & Mattingly, R. R. (2018). Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening. Experimental neurology, 299, 289-298.

Chal, J., Al Tanoury, Z., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., ... & Sumara, O. (2018). Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Development, 145
(*CHIR99021 and LDN-193189 from Axon MedChem) 

Mae, S. I., Ryosaka, M., Toyoda, T., Matsuse, K., Oshima, Y., Tsujimoto, H., ... & Osafune, K. (2018). Generation of branching ureteric bud tissues from human pluripotent stem cells. Biochemical and biophysical research communications, 495(1), 954-961. 

SHOJI, Masanobu. Method for producing dopaminergic neurons. U.S. Patent Application No 10/017,734, 2018.
*CHIR99021, LDN193189, SB431542, SHH and purmorphamine 

Kraniak, J. M., Chalasani, A., Wallace, M. R., & Mattingly, R. R. (2017). development of 3d culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening. Experimental neurology.

Astrologo, L., Zoni, E., Karkampouna, S., Gray, P. C., Klima, I., Grosjean, J., ... & Thalmann, G. N. (2017). ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models. Frontiers in cell and developmental biology, 5, 104.
Hanna, Y., Novershtern, N., & Rais, Y. (2017). Media for culturing pluripotent stem cells. U.S. Patent Application No. 15/500,163.
* LDN193189, Thiazovivin, CGP77675, DPAT, DBZ, Ly2886721, BIRB796, RU-SKI43 from Axon Medchem

Spottiswoode, N., Armitage, A. E., Williams, A. R., Fyfe, A. J., Biswas, S., Hodgson, S. H., ... & Drakesmith, H. (2017). Role of activins in hepcidin regulation during malaria. Infection and immunity, 85(12), e00191-17.

Zeng, H., Ortiz, A., Shen, P. F., Cheng, C. J., Lee, Y. C., Yu, G., ... & Lin, S. H. (2017). Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway. Oncotarget, 8(6), 10145.

Chal, J., Al Tanoury, Z., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., ... & Garnier, J. M. (2017). Recapitulating Early Development Of Mouse Musculoskeletal Precursors Of The Paraxial Mesoderm In Vitro. bioRxiv, 140574.
(CHIR99021 and LDN193189 from Axon Medchem)
Guo, G., von Meyenn, F., Rostovskaya, M., Clarke, J., Dietmann, S., Baker, D., ... & Plath, K. (2017). Epigenetic resetting of human pluripotency. bioRxiv, 146712.
Kimura, A., Toyoda, T., Nishi, Y., Nasu, M., Ohta, A., & Osafune, K. (2017). Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells. Stem Cell Research. 24, 61-68.
Hallmann, A. L., Araúzo-Bravo, M. J., Mavrommatis, L., Ehrlich, M., Röpke, A., Brockhaus, J., ... & Zaehres, H. (2017). Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Scientific Reports, 7, srep42991.
van Caam, A., Madej, W., de Vinuesa, A. G., Goumans, M. J., ten Dijke, P., Davidson, E. B., & van der Kraan, P. (2017). TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity. Arthritis Research & Therapy, 19(1), 112.
Hunt, C. P. J., Pouton, C. W., & Haynes, J. M. (2017). Characterising the developmental profile of human embryonic stem cell-derived medium spiny neuron progenitors and assessing mature neuron function using a CRISPR-generated human DARPP-32 WT/eGFP-AMP reporter line. Neurochemistry international, 106, 3-13.
(Y-27632, LDN193189, SB431542, purmorphamine and DAPT from Axon Medchem)
Drouin‐Ouellet, J., Lau, S., Brattås, P. L., Ottosson, D. R., Pircs, K., Grassi, D. A., ... & Graff, C. (2017). REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and‐independent pathways. EMBO molecular medicine, 9(8), 1117-1131.
(LSC: LDN193189, SB 432541 and CHIR99021 from Axon Medchem)
Minnerop, M., Kurzwelly, D., Wagner, H., Soehn, A. S., Reichbauer, J., Tao, F., ... & Pyle, A. (2017). Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia. Brain, 140(6), 1561-1578.
(LSB:LDN193189, SB 432541 from Axon Medchem)

Matsuno, K., Mae, S. I., Okada, C., Nakamura, M., Watanabe, A., Toyoda, T., ... & Osafune, K. (2016). Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells. Differentiation, 92(5), 281-290.
(CHIR99021 and LDN193189 from Axon Medchem)

Song, W., Tung, C. K., Lu, Y. C., Pardo, Y., Wu, M., Das, M., ... & Ma, M. (2016). Dynamic self-organization of microwell-aggregated cellular mixtures. Soft matter, 12(26), 5739-5746.

Heesen, L., Peitz, M., Torres-Benito, L., Hölker, I., Hupperich, K., Dobrindt, K., ... & Hosseini-Barkooie, S. M. (2016). Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals. Cellular and molecular life sciences, 73(10), 2089-2104.

Pfisterer, U., Ek, F., Lang, S., Soneji, S., Olsson, R., & Parmar, M. (2016). Small molecules increase direct neural conversion of human fibroblasts. Scientific reports, 6, 38290.
(CHIR99021 and LDN193189 from Axon Medchem)

Jungverdorben, J., Evert, B. O., Peitz, M., Borghese, L., & Brüstle, O. Beate Roese-Koerner, Laura Stappert, Thomas Berger, Nils Christian Braun, Monika Veltel. (2016) Reciprocal Regulation between Bifunctional miR-9/9* and its Transcriptional
Modulator Notch in Human Neural Stem Cell Self-Renewal and
Differentiation. Stem Cell Reports. 2016, 7, 207.

Osafune, Kenji, Takafumi Toyohara, and Yukiko Yamagishi. "METHOD FOR PRODUCING RENAL PROGENITOR CELLS, AND DRUG COMPRISING THE SAME." U.S. Patent No. 20,160,137,985. 19 May 2016.
*LDN193189 and Dorsomorphine

Matsuno, Kunihiko, et al. "Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells." Differentiation (2016). 

Osafune, Kenji, Takafumi Toyohara, and Yukiko Yamagishi. "METHOD FOR PRODUCING RENAL PROGENITOR CELLS, AND DRUG COMPRISING THE SAME." U.S. Patent No. 20,160,137,985. 19 May 2016. 
Zhang, Kairui, et al. "Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model." Matrix Biology 52 (2016): 315-324. 
Zhang, Zheng, Scott A. Rankin, and Aaron M. Zorn. "Syndecan4 coordinates Wnt/JNK and BMP signaling to regulate foregut progenitor development." Developmental Biology (2016). 
Zhou, Xiang, et al. "Normal gonadotropin production and fertility in gonadotrope-specific BMPR1A knockout mice." Journal of Endocrinology (2016): JOE-16. 
Stratigopoulos, George, et al. "Hypomorphism of Fto and Rpgrip1l causes obesity in mice." The Journal of clinical investigation 126.5 (2016).
LSB: LDN193189 and SB431542 from Axon Medchem 
Cai, Jie. BMP signaling in vascular and heterotopic bone diseases. Diss. Molecular Cell Biology, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, 2016. 
Lee, Yu-Chen, et al. "Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment." Molecular & Cellular Proteomics 14.3 (2015): 471-483.
*SD208, GW788388 and LDN193189 from Axon Medchem 
Song, Weihua, et al. "The fetal mouse metatarsal bone explant as a model of angiogenesis." Nature protocols 10.10 (2015): 1459-1473. 
Kajimoto, Hidemi, et al. "BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease." Kidney international 87.1 (2015): 128-136. 
Latos, Paulina A., et al. "Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells." Nature communications 6 (2015). 
Bier, Ethan, et al. "Protection and treatment against influenza infection." U.S. Patent No. 9,095,579. 4 Aug. 2015. 
Tabata, Yoshikuni, et al. "Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells." Journal of Biomolecular Screening 20.9 (2015): 1074-1083.
*CHIR99021, LDN193189, WP1066, and S31-201 from Axon Medchem 
Fukusumi, Yoshiyasu, et al. "Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse." The Journal of Neuroscience 35.39 (2015): 13385-13401.

Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.
Lavoz, C., Alique, M., Rodrigues‐Diez, R., Pato, J., Keri, G., Mezzano, S., Egido, J., & Ruiz‐Ortega, M.
J. Pathol. 2015, online 19 MAY 2015. DOI: 10.1002/path.4537

Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling.
Watmuff, B., Hartley, B. J., Hunt, C. P., Fabb, S. A., Pouton, C. W., & Haynes, J. M.
Front Cell Neurosci. 2015, 9, 104. doi: 10.3389/fncel.2015.00104

Dullard/Ctdnep1 Regulates Endochondral Ossification via Suppression of TGF‐β Signaling.
Hayata, T., Asashima, M., Nishinakamura, R., & Noda, M.
J. Bone Mineral Res. 2015, 30(2), 318-329. DOI: 10.1002/jbmr.2343

In vitro Differentiation of Pluripotent Stem Cells towards either Forebrain GABAergic or Midbrain Dopaminergic Neurons. Neural Stem Cell Assays, 91.
Hartley, B. J., Watmuff, B., Hunt, C. P.J., Haynes, J. M. and Pouton, C. W.
Neural Stem Cell Assays, 2014, 91 (eds N. Kaur and M. C. Vemuri), John Wiley & Sons, Inc, Hoboken, NJ, USA. doi: 10.1002/9781118308295.ch10
* SB431542 (Axon 1661), LDN193189 (Axon 1509) and DAPT (Axon 1484) were procured from Axon Medchem.
** Other two drugs used in this paper, CHIR99021 (Axon 1386) and Purmorphamine (Axon 1690), are also available at Axon Medchem.

Hanna, Y., Novershtern, N., & Rais, Y. (2014). U.S. Patent No. 20,140,315,301. Washington, DC: U.S.
* about 30 inhibitors has been cited from Axon Medchem 

Dullard/Ctdnep1 Regulates Endochondral Ossification via Suppression of TGF‐ß Signaling.
Hayata, T., Ezura, Y., Asashima, M., Nishinakamura, R., & Noda, M. 
Cytokine (IL16) and tyrphostin actions on ovarian primordial follicle development. 
Feeney, A., Nilsson, E., & Skinner, M. K. 
BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease. 
H Kajimoto, H Kai, H Aoki, H Uchiwa, Y Aoki, S Yasuoka, T Anegawa, Y Mishina, A Suzuki, Y Fukumoto and T Imaizumi.
Bone Morphogenetic Protein 2 Stimulates Noncanonical SMAD2/3 Signaling via the BMP Type 1A Receptor in Gonadotrope-Like Cells: Implications for FSH Synthesis. 
Y Wang, CC Ho, E Bang, CA Rejon, V Libasci, P Pertchenko, TE Hébert, and DJ Bernard.
Engineering of midbrain organoids containing long-lived dopaminergic neurons. 
Tieng, V., Stoppini, L., Villy, S., Fathi, M., Dubois-Dauphin, M., & Krause, K. H. 
*LDN 193189, SB431542 and CHIR 99021 were procured from Axon Medchem.
Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer. 
Liu, C. W., Li, C. H., Yi-Jen, P., Cheng, Y. W., Chen, H. W., Liao, P. L., Kang, J. J., & Yeng, M. H. 
BMP signaling balances murine myeloid potential through SMAD-independent p38MAPK and NOTCH pathways. 
Cook, B. D., & Evans, T. 
Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats. 
M Theurl, M Nairz, A Schroll, T Sonnweber, M ABhoff, D Haschka, M Seifert, W Willenbacher, D Wilflingseder, W Posch, AT Murphy, DR Witcher, I Theurl, G Weiss.
BMP signaling controls muscle mass.
R Sartori, E Schirwis, B Blaauw, S Bortolanza, J Zhao, E Enzo, A Stantzou, E Mouisel, L Toniolo, A Ferry, S Stricker, AL Goldberg, S Dupont, S Piccolo, H Amthor & M Sandri.
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.
X Wang, S Abraham,  JAG McKenzie, N Jeffs, M Swire, VB Tripathi, UFO Luhmann, CAK Lange, Z Zhai, HM Arthur,  JWB Bainbridge, SE Moss & J Greenwood.
Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis.
PW Voorneveld, V Stache, RJ Jacobs, E Smolders, AI Sitters, A Liesker, KS Korkmaz, SM Lam, NFCC De Miranda, H Morreau, LL Kodach and JCH Hardwick.
DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT.
L Schneider, S Pellegatta, R Favaro, F Pisati, P Roncaglia, G Testa, SK Nicolis, G Finocchiaro, F d’Adda di Fagagna.
Macrophage coculture enhanced invasion of gastric cancer cells via TGF-β and BMP pathways.
Z Shen, T Kauttu, J Cao, H Seppänen, S Vainionpää, Y Ye, S Wang, H Mustonen & P Puolakkainen.
Vasohibin-1 Expression Is Regulated by Transforming Growth Factor-β/Bone Morphogenic Protein Signaling Pathway Between Tumor-Associated Macrophages and Pancreatic Cancer Cells.
Z Shen, H Seppänen, T Kauttu, S Vainionpää, Y Ye, S Wang, H Mustonen, P Puolakkainen. 
Essential role of Bmp signaling and its positive feedback loop in the early cell fate evolution of chordates.
I Kozmikova, S Candiani, P Fabian, D Gurska, Z Kozmik.
Protection and Treatment Against Influenza Infection.
Bier, E., Smelkinson, M., Krug, R., Malur, M., Oldstone, M., & Teijaro, J. (2013).
U.S. Patent No. 20,130,203,793.
M Hosoya, Y Kunisada, M Shoji… 
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
C Besson-Fournier, C Latour, L Kautz, J Bertrand, T Ganz, MP Roth, H Coppin.
Activation of the Canonical Bone Morphogenetic Protein (BMP) Pathway during Lung Morphogenesis and Adult Lung Tissue Repair.
A Sountoulidis, A Stavropoulos, S Giaglis, E Apostolou, R Monteiro, SMC de Sousa Lopes, H Chen, BR Stripp, C Mummery, E Andreakos, P Sideras.
Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
SA Rankin, AL Gallas, A Neto, JL Gómez-Skarmeta, AM Zorn.
Sizzled-Tolloid Interactions Maintain Foregut Progenitors by Regulating Fibronectin-Dependent BMP Signaling.
AP Kenny, SA Rankin, AW Allbee, AR Prewitt, Z Zhang, ME Tabangin, ET Shifley, MP Louza, AM Zorn. 
BMP4 promotes prostate tumor growth in bone through osteogenesis.
YC Lee, CJ Cheng, MA Bilen, JF Lu, RL Satcher, LY Yu-Lee, GE Gallick, SN Maity, SH Lin.
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