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Axon 1509 - Publications

List of publications using LDN 193189 (Axon 1509) purchased from Axon Medchem

(Total 68 publication citations listed; updated MAY-2019)

2019
Eddowes, L. A., Al-Hourani, K., Ramamurthy, N., Frankish, J., Baddock, H. T., Sandor, C., ... & Boninsegna, S. (2019). Antiviral activity of bone morphogenetic proteins and activins. Nature microbiology, 4(2), 339.
https://www.nature.com/articles/s41564-018-0301-9

Mae, S. I., Ryosaka, M., & Osafune, K. (2019). Protocol to Generate Ureteric Bud Structures from Human iPS Cells. In Kidney Organogenesis (pp. 117-123). Humana Press, New York, NY.

Rostovskaya, M., Stirparo, G. G., & Smith, A. (2019). Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development, 146(7), dev172916.

2018
OSAFUNE, Kenji; TOYODA, Taro; KIMURA, Azuma. Method for producing pancreatic bud cells. U.S. Patent Application No 15/760,523, 2018.
*LDN193189 and CHIR99021 from Axon Medchem

Kraniak, J. M., Chalasani, A., Wallace, M. R., & Mattingly, R. R. (2018). Development of 3D culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening. Experimental neurology, 299, 289-298.
https://www.sciencedirect.com/science/article/pii/S0014488617302728

Chal, J., Al Tanoury, Z., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., ... & Sumara, O. (2018). Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro. Development, 145
http://dev.biologists.org/content/145/6/dev157339
(*CHIR99021 and LDN-193189 from Axon MedChem) 

Mae, S. I., Ryosaka, M., Toyoda, T., Matsuse, K., Oshima, Y., Tsujimoto, H., ... & Osafune, K. (2018). Generation of branching ureteric bud tissues from human pluripotent stem cells. Biochemical and biophysical research communications, 495(1), 954-961.
https://www.sciencedirect.com/science/article/pii/S0006291X17322842 

SHOJI, Masanobu. Method for producing dopaminergic neurons. U.S. Patent Application No 10/017,734, 2018.
https://patents.google.com/patent/US10017734B2/en
*CHIR99021, LDN193189, SB431542, SHH and purmorphamine 

2017
Kraniak, J. M., Chalasani, A., Wallace, M. R., & Mattingly, R. R. (2017). development of 3d culture models of plexiform neurofibroma and initial application for phenotypic characterization and drug screening. Experimental neurology.
https://www.sciencedirect.com/science/article/pii/S0014488617302728

Astrologo, L., Zoni, E., Karkampouna, S., Gray, P. C., Klima, I., Grosjean, J., ... & Thalmann, G. N. (2017). ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models. Frontiers in cell and developmental biology, 5, 104.
https://www.frontiersin.org/articles/10.3389/fcell.2017.00104/full
 
Hanna, Y., Novershtern, N., & Rais, Y. (2017). Media for culturing pluripotent stem cells. U.S. Patent Application No. 15/500,163.
https://patents.google.com/patent/US20170275593A1/en
* LDN193189, Thiazovivin, CGP77675, DPAT, DBZ, Ly2886721, BIRB796, RU-SKI43 from Axon Medchem

Spottiswoode, N., Armitage, A. E., Williams, A. R., Fyfe, A. J., Biswas, S., Hodgson, S. H., ... & Drakesmith, H. (2017). Role of activins in hepcidin regulation during malaria. Infection and immunity, 85(12), e00191-17.
http://iai.asm.org/content/85/12/e00191-17.short

Zeng, H., Ortiz, A., Shen, P. F., Cheng, C. J., Lee, Y. C., Yu, G., ... & Lin, S. H. (2017). Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway. Oncotarget, 8(6), 10145.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354648/

Chal, J., Al Tanoury, Z., Oginuma, M., Moncuquet, P., Gobert, B., Miyanari, A., ... & Garnier, J. M. (2017). Recapitulating Early Development Of Mouse Musculoskeletal Precursors Of The Paraxial Mesoderm In Vitro. bioRxiv, 140574.
(CHIR99021 and LDN193189 from Axon Medchem)
 
Guo, G., von Meyenn, F., Rostovskaya, M., Clarke, J., Dietmann, S., Baker, D., ... & Plath, K. (2017). Epigenetic resetting of human pluripotency. bioRxiv, 146712.
 
Kimura, A., Toyoda, T., Nishi, Y., Nasu, M., Ohta, A., & Osafune, K. (2017). Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells. Stem Cell Research. 24, 61-68.
 
Hallmann, A. L., Araúzo-Bravo, M. J., Mavrommatis, L., Ehrlich, M., Röpke, A., Brockhaus, J., ... & Zaehres, H. (2017). Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Scientific Reports, 7, srep42991.
 
van Caam, A., Madej, W., de Vinuesa, A. G., Goumans, M. J., ten Dijke, P., Davidson, E. B., & van der Kraan, P. (2017). TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity. Arthritis Research & Therapy, 19(1), 112.
 
Hunt, C. P. J., Pouton, C. W., & Haynes, J. M. (2017). Characterising the developmental profile of human embryonic stem cell-derived medium spiny neuron progenitors and assessing mature neuron function using a CRISPR-generated human DARPP-32 WT/eGFP-AMP reporter line. Neurochemistry international, 106, 3-13.
(Y-27632, LDN193189, SB431542, purmorphamine and DAPT from Axon Medchem)
 
Drouin‐Ouellet, J., Lau, S., Brattås, P. L., Ottosson, D. R., Pircs, K., Grassi, D. A., ... & Graff, C. (2017). REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and‐independent pathways. EMBO molecular medicine, 9(8), 1117-1131.
(LSC: LDN193189, SB 432541 and CHIR99021 from Axon Medchem)
 
Minnerop, M., Kurzwelly, D., Wagner, H., Soehn, A. S., Reichbauer, J., Tao, F., ... & Pyle, A. (2017). Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia. Brain, 140(6), 1561-1578.
(LSB:LDN193189, SB 432541 from Axon Medchem)

2016
Matsuno, K., Mae, S. I., Okada, C., Nakamura, M., Watanabe, A., Toyoda, T., ... & Osafune, K. (2016). Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells. Differentiation, 92(5), 281-290.
http://www.sciencedirect.com/science/article/pii/S0301468116300238
(CHIR99021 and LDN193189 from Axon Medchem)

Song, W., Tung, C. K., Lu, Y. C., Pardo, Y., Wu, M., Das, M., ... & Ma, M. (2016). Dynamic self-organization of microwell-aggregated cellular mixtures. Soft matter, 12(26), 5739-5746.
http://pubs.rsc.org/-/content/articlehtml/2016/sm/c6sm00456c

Heesen, L., Peitz, M., Torres-Benito, L., Hölker, I., Hupperich, K., Dobrindt, K., ... & Hosseini-Barkooie, S. M. (2016). Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals. Cellular and molecular life sciences, 73(10), 2089-2104.
https://link.springer.com/article/10.1007/s00018-015-2084-y

Pfisterer, U., Ek, F., Lang, S., Soneji, S., Olsson, R., & Parmar, M. (2016). Small molecules increase direct neural conversion of human fibroblasts. Scientific reports, 6, 38290.
https://www.nature.com/articles/srep38290?WT.feed_name=subjects_stem-cell-research
(CHIR99021 and LDN193189 from Axon Medchem)

Jungverdorben, J., Evert, B. O., Peitz, M., Borghese, L., & Brüstle, O. Beate Roese-Koerner, Laura Stappert, Thomas Berger, Nils Christian Braun, Monika Veltel. (2016) Reciprocal Regulation between Bifunctional miR-9/9* and its Transcriptional
Modulator Notch in Human Neural Stem Cell Self-Renewal and
Differentiation. Stem Cell Reports. 2016, 7, 207.
http://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(16)30100-X

Osafune, Kenji, Takafumi Toyohara, and Yukiko Yamagishi. "METHOD FOR PRODUCING RENAL PROGENITOR CELLS, AND DRUG COMPRISING THE SAME." U.S. Patent No. 20,160,137,985. 19 May 2016.
http://www.freepatentsonline.com/y2016/0137985.html
*LDN193189 and Dorsomorphine

Matsuno, Kunihiko, et al. "Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells." Differentiation (2016).
http://www.sciencedirect.com/science/article/pii/S0301468116300238 

Osafune, Kenji, Takafumi Toyohara, and Yukiko Yamagishi. "METHOD FOR PRODUCING RENAL PROGENITOR CELLS, AND DRUG COMPRISING THE SAME." U.S. Patent No. 20,160,137,985. 19 May 2016.
http://www.freepatentsonline.com/y2016/0137985.html 
 
Zhang, Kairui, et al. "Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model." Matrix Biology 52 (2016): 315-324.
http://www.sciencedirect.com/science/article/pii/S0945053X16300099 
 
Zhang, Zheng, Scott A. Rankin, and Aaron M. Zorn. "Syndecan4 coordinates Wnt/JNK and BMP signaling to regulate foregut progenitor development." Developmental Biology (2016).
http://www.sciencedirect.com/science/article/pii/S0012160616300112 
 
Zhou, Xiang, et al. "Normal gonadotropin production and fertility in gonadotrope-specific BMPR1A knockout mice." Journal of Endocrinology (2016): JOE-16.
http://joe.endocrinology-journals.org/content/early/2016/03/30/JOE-16-0053.abstract 
 
Stratigopoulos, George, et al. "Hypomorphism of Fto and Rpgrip1l causes obesity in mice." The Journal of clinical investigation 126.5 (2016).
http://www.jci.org/articles/view/85526
LSB: LDN193189 and SB431542 from Axon Medchem 
 
Cai, Jie. BMP signaling in vascular and heterotopic bone diseases. Diss. Molecular Cell Biology, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University, 2016.
https://openaccess.leidenuniv.nl/handle/1887/38502 
 
2015
Lee, Yu-Chen, et al. "Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment." Molecular & Cellular Proteomics 14.3 (2015): 471-483.
https://www.mcponline.org/content/14/3/471.full
*SD208, GW788388 and LDN193189 from Axon Medchem 
 
Song, Weihua, et al. "The fetal mouse metatarsal bone explant as a model of angiogenesis." Nature protocols 10.10 (2015): 1459-1473.
http://www.nature.com/nprot/journal/v10/n10/full/nprot.2015.097.html 
 
Kajimoto, Hidemi, et al. "BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease." Kidney international 87.1 (2015): 128-136.
http://www.nature.com/ki/journal/v87/n1/abs/ki2014223a.html 
 
Latos, Paulina A., et al. "Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells." Nature communications 6 (2015).
http://www.nature.com/ncomms/2015/150724/ncomms8776/full/ncomms8776.html 
 
Bier, Ethan, et al. "Protection and treatment against influenza infection." U.S. Patent No. 9,095,579. 4 Aug. 2015.
https://www.google.com/patents/US9095579 
 
Tabata, Yoshikuni, et al. "Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells." Journal of Biomolecular Screening 20.9 (2015): 1074-1083.
http://jbx.sagepub.com/content/20/9/1074.full
*CHIR99021, LDN193189, WP1066, and S31-201 from Axon Medchem 
 
Fukusumi, Yoshiyasu, et al. "Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse." The Journal of Neuroscience 35.39 (2015): 13385-13401.
https://www.jneurosci.org/content/35/39/13385.full

Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.
Lavoz, C., Alique, M., Rodrigues‐Diez, R., Pato, J., Keri, G., Mezzano, S., Egido, J., & Ruiz‐Ortega, M.
J. Pathol. 2015, online 19 MAY 2015. DOI: 10.1002/path.4537

Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling.
Watmuff, B., Hartley, B. J., Hunt, C. P., Fabb, S. A., Pouton, C. W., & Haynes, J. M.
Front Cell Neurosci. 2015, 9, 104. doi: 10.3389/fncel.2015.00104

Dullard/Ctdnep1 Regulates Endochondral Ossification via Suppression of TGF‐β Signaling.
Hayata, T., Asashima, M., Nishinakamura, R., & Noda, M.
J. Bone Mineral Res. 2015, 30(2), 318-329. DOI: 10.1002/jbmr.2343

2014
In vitro Differentiation of Pluripotent Stem Cells towards either Forebrain GABAergic or Midbrain Dopaminergic Neurons. Neural Stem Cell Assays, 91.
Hartley, B. J., Watmuff, B., Hunt, C. P.J., Haynes, J. M. and Pouton, C. W.
Neural Stem Cell Assays, 2014, 91 (eds N. Kaur and M. C. Vemuri), John Wiley & Sons, Inc, Hoboken, NJ, USA. doi: 10.1002/9781118308295.ch10
* SB431542 (Axon 1661), LDN193189 (Axon 1509) and DAPT (Axon 1484) were procured from Axon Medchem.
** Other two drugs used in this paper, CHIR99021 (Axon 1386) and Purmorphamine (Axon 1690), are also available at Axon Medchem.

ISOLATED NAIVE PLURIPOTENT STEM CELLS AND METHODS OF GENERATING SAME.
Hanna, Y., Novershtern, N., & Rais, Y. (2014). U.S. Patent No. 20,140,315,301. Washington, DC: U.S.
* about 30 inhibitors has been cited from Axon Medchem 

Dullard/Ctdnep1 Regulates Endochondral Ossification via Suppression of TGF‐ß Signaling.
Hayata, T., Ezura, Y., Asashima, M., Nishinakamura, R., & Noda, M. 
 
Cytokine (IL16) and tyrphostin actions on ovarian primordial follicle development. 
Feeney, A., Nilsson, E., & Skinner, M. K. 
 
BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease. 
H Kajimoto, H Kai, H Aoki, H Uchiwa, Y Aoki, S Yasuoka, T Anegawa, Y Mishina, A Suzuki, Y Fukumoto and T Imaizumi.
 
Bone Morphogenetic Protein 2 Stimulates Noncanonical SMAD2/3 Signaling via the BMP Type 1A Receptor in Gonadotrope-Like Cells: Implications for FSH Synthesis. 
Y Wang, CC Ho, E Bang, CA Rejon, V Libasci, P Pertchenko, TE Hébert, and DJ Bernard.
 
Engineering of midbrain organoids containing long-lived dopaminergic neurons. 
Tieng, V., Stoppini, L., Villy, S., Fathi, M., Dubois-Dauphin, M., & Krause, K. H. 
*LDN 193189, SB431542 and CHIR 99021 were procured from Axon Medchem.
 
Snail regulates Nanog status during the epithelial–mesenchymal transition via the Smad1/Akt/GSK3β signaling pathway in non-small-cell lung cancer. 
Liu, C. W., Li, C. H., Yi-Jen, P., Cheng, Y. W., Chen, H. W., Liao, P. L., Kang, J. J., & Yeng, M. H. 
 
BMP signaling balances murine myeloid potential through SMAD-independent p38MAPK and NOTCH pathways. 
Cook, B. D., & Evans, T. 
 
Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats. 
M Theurl, M Nairz, A Schroll, T Sonnweber, M ABhoff, D Haschka, M Seifert, W Willenbacher, D Wilflingseder, W Posch, AT Murphy, DR Witcher, I Theurl, G Weiss.
 
BMP signaling controls muscle mass.
R Sartori, E Schirwis, B Blaauw, S Bortolanza, J Zhao, E Enzo, A Stantzou, E Mouisel, L Toniolo, A Ferry, S Stricker, AL Goldberg, S Dupont, S Piccolo, H Amthor & M Sandri.
 
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.
X Wang, S Abraham,  JAG McKenzie, N Jeffs, M Swire, VB Tripathi, UFO Luhmann, CAK Lange, Z Zhai, HM Arthur,  JWB Bainbridge, SE Moss & J Greenwood.
 
Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis.
PW Voorneveld, V Stache, RJ Jacobs, E Smolders, AI Sitters, A Liesker, KS Korkmaz, SM Lam, NFCC De Miranda, H Morreau, LL Kodach and JCH Hardwick.
 
DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT.
L Schneider, S Pellegatta, R Favaro, F Pisati, P Roncaglia, G Testa, SK Nicolis, G Finocchiaro, F d’Adda di Fagagna.
 
Macrophage coculture enhanced invasion of gastric cancer cells via TGF-β and BMP pathways.
Z Shen, T Kauttu, J Cao, H Seppänen, S Vainionpää, Y Ye, S Wang, H Mustonen & P Puolakkainen.
 
Vasohibin-1 Expression Is Regulated by Transforming Growth Factor-β/Bone Morphogenic Protein Signaling Pathway Between Tumor-Associated Macrophages and Pancreatic Cancer Cells.
Z Shen, H Seppänen, T Kauttu, S Vainionpää, Y Ye, S Wang, H Mustonen, P Puolakkainen. 
 
Essential role of Bmp signaling and its positive feedback loop in the early cell fate evolution of chordates.
I Kozmikova, S Candiani, P Fabian, D Gurska, Z Kozmik.
 
Protection and Treatment Against Influenza Infection.
Bier, E., Smelkinson, M., Krug, R., Malur, M., Oldstone, M., & Teijaro, J. (2013).
U.S. Patent No. 20,130,203,793.
 
METHOD FOR MANUFACTURING PANCREATIC-HORMONE-PRODUCING CELLS.
M Hosoya, Y Kunisada, M Shoji… 
 
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
C Besson-Fournier, C Latour, L Kautz, J Bertrand, T Ganz, MP Roth, H Coppin.
 
Activation of the Canonical Bone Morphogenetic Protein (BMP) Pathway during Lung Morphogenesis and Adult Lung Tissue Repair.
A Sountoulidis, A Stavropoulos, S Giaglis, E Apostolou, R Monteiro, SMC de Sousa Lopes, H Chen, BR Stripp, C Mummery, E Andreakos, P Sideras.
 
Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
SA Rankin, AL Gallas, A Neto, JL Gómez-Skarmeta, AM Zorn.
 
Sizzled-Tolloid Interactions Maintain Foregut Progenitors by Regulating Fibronectin-Dependent BMP Signaling.
AP Kenny, SA Rankin, AW Allbee, AR Prewitt, Z Zhang, ME Tabangin, ET Shifley, MP Louza, AM Zorn. 
 
BMP4 promotes prostate tumor growth in bone through osteogenesis.
YC Lee, CJ Cheng, MA Bilen, JF Lu, RL Satcher, LY Yu-Lee, GE Gallick, SN Maity, SH Lin.

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