List of publications using LDN 193189 (Axon 1509) purchased from Axon Medchem

(Total 112 publication citations listed; updated up to July 2023)

2023
Ito, R., Kimura, A., Hirose, Y., Hatano, Y., Mima, A., Mae, S. I., ... & Osafune, K. (2023). Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model. Scientific Reports, 13(1), 8659.
https://www.nature.com/articles/s41598-023-35875-1

Naito, Y., Sakamoto, S., Kojima, T., Homma, M., Tanaka, M., & Matsui, H. (2023). Novel beta-Glucocerebrosidase Chaperone Compounds Identified from Cell-based Screening Reduce Pathologically Accumulated Glucosylsphingosine in iPS-derived Neuronal Cells. SLAS Discovery.
https://www.sciencedirect.com/science/article/pii/S2472555223000485
* CHIR99021 and LDN193189 from Axon Medchem

Mae, S. I., Hattanda, F., Morita, H., Nozaki, A., Katagiri, N., Ogawa, H., ... & Osafune, K. (2023). Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD. Cell Reports.
https://www.cell.com/cell-reports/pdf/S2211-1247(23)01443-2.pdf
* LDN193189 and tolvaptan from Axon Medchem

2022
Bricker, R. L., Bhaskar, U., Titone, R., Carless, M. A., & Barberi, T. (2022). A molecular analysis of neural olfactory placode differentiation in human pluripotent stem cells. Stem Cells and Development, 31(17-18), 507-520.
https://www.liebertpub.com/doi/abs/10.1089/scd.2021.0257

Ryosaka, M., Mae, S. I., & Osafune, K. (2022). Protocol for the generation and expansion of human iPS cell-derived ureteric bud organoids. STAR protocols, 3(3), 101484.
https://www.sciencedirect.com/science/article/pii/S2666166722003641

Rousset, F., Schilardi, G., Sgroi, S., Nacher-Soler, G., Sipione, R., Kleinlogel, S., & Senn, P. (2022). WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro. Cells, 11(15), 2431.
https://www.mdpi.com/2073-4409/11/15/2431
* CHIR99021, SB431542 and LDN193189 from Axon Medchem

Yamamoto, T., Sato, Y., Yasuda, S., Shikamura, M., Tamura, T., Takenaka, C., ... & Kawamata, S. (2022). Correlation Between Genetic Abnormalities in Induced Pluripotent Stem Cell-Derivatives and Abnormal Tissue Formation in Tumorigenicity Tests. Stem Cells Translational Medicine, 11(5), 527-538.
https://academic.oup.com/stcltm/article/11/5/527/6571698

Lesage, R., Ferrao Blanco, M. N., Narcisi, R., Welting, T., van Osch, G. J., & Geris, L. (2022). An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis. Bmc Biology, 20(1), 253.
https://link.springer.com/article/10.1186/s12915-022-01451-8
*Foskolin, PD0325901, PD161570, LDN193189, LY294002 from Axon Medchem

Röderer, P., Belu, A., Heidrich, L., Siobal, M., Isensee, J., Prolingheuer, J., ... & Hucho, T. (2022). Emergence of nociceptive functionality and opioid signaling in human iPSC-derived sensory neurons. Pain, 10-1097.
https://journals.lww.com/pain/fulltext/2023/08000/emergence_of_nociceptive_functionality_and_opioid.9.aspx
* LDN193189 and DAPT from Axon Medchem

Rostovskaya, M., Andrews, S., Reik, W., & Rugg-Gunn, P. J. (2022). Amniogenesis occurs in two independent waves in primates. Cell Stem Cell, 29(5), 744-759.
https://www.cell.com/cell-stem-cell/pdf/S1934-5909(22)00112-6.pdf

Glinkina, K., Groenewoud, A., Teunisse, A. F., Snaar-Jagalska, B. E., & Jochemsen, A. G. (2022). Novel treatments of uveal melanoma identified with a synthetic lethal CRISPR/Cas9 screen. Cancers, 14(13), 3186.
https://www.mdpi.com/2072-6694/14/13/3186

Rodriguez-Gatica, J. E., Iefremova, V., Sokhranyaeva, L., Yeung, S. W. C. A., Breitkreuz, Y., Brüstle, O., ... & Kubitscheck, U. (2022). Imaging three-dimensional brain organoid architecture from meso-to nanoscale across development. Development, 149(20), dev200439.
https://journals.biologists.com/dev/article/149/20/dev200439/276224/Imaging-three-dimensional-brain-organoid

2021
Preisler, L., Habib, A., Shapira, G., Kuznitsov-Yanovsky, L., Mayshar, Y., Carmel-Gross, I., ... & Ben-Yosef, D. (2021). Heterozygous APC germline mutations impart predisposition to colorectal cancer. Scientific reports, 11(1), 5113.
https://www.nature.com/articles/s41598-021-84564-4
* CHIR99021, LDN193189 and Y27632 from Axon Medchem

Tong, Z., Kwak, E., Aguiar, A., Peng, B., Pouton, C. W., Voelcker, N. H., & Haynes, J. M. (2021). Compartmentalized microfluidic chambers enable long-term maintenance and communication between human pluripotent stem cell-derived forebrain and midbrain neurons. Lab on a Chip, 21(20), 4016-4030.
https://pubs.rsc.org/en/content/articlehtml/2021/lc/d1lc00505g

Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., ... & Hanna, J. H. (2021). Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell stem cell, 28(9), 1549-1565.
https://www.cell.com/cell-stem-cell/pdf/S1934-5909(21)00158-2.pdf
* LDN193189, CHIR99021, PD0325901, IWR1, BIRB0796, GO6983, Y27632, CGP77675, RIN1, A 83-01, SB590895, BIX02189, RU-SKI43 and BIX01294 from Axon Medchem

Hoffmann, A., de Souza, L. V., Seifert, M., von Raffay, L., Haschka, D., Grubwieser, P., ... & Weiss, G. (2021). Pharmacological targeting of BMP6-SMAD mediated hepcidin expression does not improve the outcome of systemic infections with intra-or extracellular gram-negative bacteria in mice. Frontiers in Cellular and Infection Microbiology, 11, 705087.
https://www.frontiersin.org/articles/10.3389/fcimb.2021.705087/full

Fukusumi, H., Togo, K., Sumida, M., Nakamori, M., Obika, S., Baba, K., ... & Kanemura, Y. (2021). Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication. FEBS Open bio, 11(2), 354-366.
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.13060

Akiyama, T., Sato, S., Ko, S. B., Sano, O., Sato, S., Saito, M., ... & Iwata, H. (2021). Synthetic mRNA-based differentiation method enables early detection of Parkinson's phenotypes in neurons derived from Gaucher disease-induced pluripotent stem cells. Stem Cells Translational Medicine, 10(4), 572-581.
https://academic.oup.com/stcltm/article/10/4/572/6404084

Togo, K., Fukusumi, H., Shofuda, T., Ohnishi, H., Yamazaki, H., Hayashi, M. K., ... & Kanemura, Y. (2021). Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro. Molecular Brain, 14(1), 1-17.
https://molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00851-1

Bakker, W., Dingenouts, C. K., Lodder, K., Wiesmeijer, K. C., de Jong, A., Kurakula, K., ... & Goumans, M. J. T. (2021). BMP receptor inhibition enhances tissue repair in endoglin heterozygous mice. International journal of molecular sciences, 22(4), 2010.
https://www.mdpi.com/1422-0067/22/4/2010

Duan, X., Tang, X., Nair, M. S., Zhang, T., Qiu, Y., Zhang, W., ... & Chen, S. (2021). An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell Reports, 37(6).
https://www.cell.com/cell-reports/pdf/S2211-1247(21)01393-0.pdf

Liu, L., Zhang, C., Wang, J., Liu, X., Qu, H., Zhang, G., ... & Zhang, J. (2021). A high level of lncFGD5-AS1 inhibits epithelial-to-Mesenchymal transition by regulating the miR-196a-5p/SMAD6/BMP axis in gastric Cancer. BMC cancer, 21(1), 1-14.
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-08192-x

Lesage, R., Ferrao Blanco, M. N., Narcisi, R., Welting, T., van Osch, G. J., & Geris, L. (2021). An integrated in silico-in vitro approach for identification of therapeutic drug targets for osteoarthritis. bioRxiv, 2021-09.
https://www.biorxiv.org/content/10.1101/2021.09.27.461207v2.full
* LDN193189, Fosklin, PD0325901, LY294002 and PD161570 from Axon Medchem

Repudi, S., Steinberg, D. J., Elazar, N., Breton, V. L., Aquilino, M. S., Saleem, A., ... & Aqeilan, R. I. (2021). Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects. Brain, 144(10), 3061-3077.
https://academic.oup.com/brain/article/144/10/3061/6259140

Bakker, W., Dingenouts, C. K. E., Lodder, K., Wiesmeijer, K. C., Jong, A. de, Kurakula, K., ... Goumans, M. J. T. H. (2021). BMP receptor inhibition enhances tissue repair in endoglin heterozygous mice. International Journal Of Molecular Sciences, 22(4). doi:10.3390/ijms22042010
https://scholarlypublications.universiteitleiden.nl/access/item%3A3308503/download

Steinberg, D. J., Repudi, S., Saleem, A., Kustanovich, I., Viukov, S., Abudiab, B., ... & Aqeilan, R. I. (2021). Modeling genetic epileptic encephalopathies using brain organoids. EMBO Molecular Medicine, 13(8), e13610.
https://www.embopress.org/doi/abs/10.15252/emmm.202013610
* CHIR99021, A 83-01 and LDN193189 from Axon Medchem

Kinoshita, M., Barber, M., Mansfield, W., Cui, Y., Spindlow, D., Stirparo, G. G., ... & Smith, A. (2021). Capture of mouse and human stem cells with features of formative pluripotency. Cell stem cell, 28(3), 453-471.
https://www.cell.com/cell-stem-cell/pdf/S1934-5909(20)30543-9.pdf

Norapat, N. (2021). Investigation of Induced-Lung Progenitor Cell Differentiation Methods.
https://naist.repo.nii.ac.jp/record/11868/files/R016864.pdf

Sedlmeier, G., Al‐Rawi, V., Buchert, J., Yserentant, K., Rothley, M., Steshina, A., ... & Sleeman, J. P. (2021). Id1 and Id3 Are Regulated Through Matrix‐Assisted Autocrine BMP Signaling and Represent Therapeutic Targets in Melanoma. Advanced Therapeutics, 4(2), 2000065.
https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202000065

Kwak, E. (2021). Evaluating the effect of Amyloid β on inflammatory response and synaptic health of forebrain neurons derived from human embryonic stem cells (Doctoral dissertation, Monash University).
https://scholar.archive.org/work/or352w5rana5rmw2dm5ixgx6wm/access/wayback/https://au-east.erc.monash.edu.au/fpfiles/39625864/PhDThesis_EunbiClaraKwak_Final.pdf?AWSAccessKeyId=e00145a6f706457aab45051570081e49&Expires=1683743618&Signature=Rb0w%2ByoMGQ2rgd2eqnWPZxvMqxI%3D

2020
Uchimura, K., Wu, H., Yoshimura, Y., & Humphreys, B. D. (2020). Human pluripotent stem cell-derived kidney organoids with improved collecting duct maturation and injury modeling. Cell reports, 33(11).
https://www.cell.com/cell-reports/pdf/S2211-1247(20)31503-5.pdf

Mae, S. I., Ryosaka, M., Sakamoto, S., Matsuse, K., Nozaki, A., Igami, M., ... & Osafune, K. (2020). Expansion of human iPSC-derived ureteric bud organoids with repeated branching potential. Cell reports, 32(4).
https://www.cell.com/cell-reports/pdf/S2211-1247(20)30944-X.pdf

Kidwai, F., Mui, B. W., Arora, D., Iqbal, K., Hockaday, M., Castro Diaz, L. F., ... & Robey, P. G. (2020). Lineage-specific differentiation of osteogenic progenitors from pluripotent stem cells reveals the FGF1-RUNX2 association in neural crest-derived osteoprogenitors. Stem Cells, 38(9), 1107-1123.
https://academic.oup.com/stmcls/article/38/9/1107/6409388

Zorzan, I., Pellegrini, M., Arboit, M., Incarnato, D., Maldotti, M., Forcato, M., ... & Martello, G. (2020). The transcriptional regulator ZNF398 mediates pluripotency and epithelial character downstream of TGF-beta in human PSCs. Nature Communications, 11(1), 2364.
https://www.nature.com/articles/s41467-020-16205-9
* Y27632, SB431542 and LDN193189 from Axon Medchem

Bayerl, J., Ayyash, M., Shani, T., Manor, Y., Gafni, O., Kalma, Y., ... & Hanna, J. H. (2020). Tripartite inhibition of SRC-WNT-PKC signalling consolidates human naïve pluripotency. bioRxiv, 2020-05.
https://www.biorxiv.org/content/10.1101/2020.05.23.112433v1.full
* LDN193189, CHIR99021, PD0325901, XAV939, Y27632, CGP77675, GO6983, IWR1, BIRB796, A8301, DBZ, SB590895, BIX01294 and BIX02189 from Axon Medchem

2019
Malaguti, M., Migueles, R. P., Blin, G., Lin, C. Y., & Lowell, S. (2019). Id1 stabilizes epiblast identity by sensing delays in nodal activation and adjusting the timing of differentiation. Developmental Cell, 50(4), 462-477.
https://www.cell.com/developmental-cell/pdf/S1534-5807(19)30445-9.pdf
* CHIR99021, PD0325901 and LDN193189 from Axon Medchem

Rhee, H. J., Shaib, A. H., Rehbach, K., Lee, C., Seif, P., Thomas, C., ... & Rhee, J. S. (2019). An autaptic culture system for standardized analyses of iPSC-derived human neurons. Cell reports, 27(7), 2212-2228.
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30532-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124719305327%3Fshowall%3Dtrue
* SB431542 and LDN193189 from Axon Medchem

Dingenouts, C. K., Bakker1&, W., Lodder, K., Wiesmeijer, K. C., Moerkamp, A. T., Mager, H. J. J., ... & Goumans, M. J. (2019). BMP receptor inhibition enhances tissue repair in endoglin heterozygous mice. Influencing the homing and differentiation of MNCs in hereditary hemorrhagic telangiectasia, 69.
https://scholarlypublications.universiteitleiden.nl/access/item%3A2977207/download#page=70

Cosset, E., Locatelli, M., Marteyn, A., Lescuyer, P., Antonia, F. D., Mor, F. M., ... & Tieng, V. (2019). Human neural organoids for studying brain cancer and neurodegenerative diseases. JoVE (Journal of Visualized Experiments), (148), e59682.
https://www.jove.com/t/59682/human-neural-organoids-for-studying-brain-cancer-neurodegenerative
* CHIR99021 and LDN193189 from Axon Medchem

Giulitti, S., Pellegrini, M., Zorzan, I., Martini, P., Gagliano, O., Mutarelli, M., ... & Martello, G. (2019). Direct generation of human naive induced pluripotent stem cells from somatic cells in microfluidics. Nature cell biology, 21(2), 275-286.
https://www.nature.com/articles/s41556-018-0254-5
* CHIR99021, PD0325901, GO6983, SB431542 and LDN193189 from Axon Medchem

Meijer, M., Rehbach, K., Brunner, J. W., Classen, J. A., Lammertse, H. C., van Linge, L. A., ... & Verhage, M. (2019). A single-cell model for synaptic transmission and plasticity in human iPSC-derived neurons. Cell reports, 27(7), 2199-2211.
https://www.cell.com/cell-reports/pdf/S2211-1247(19)30531-5.pdf
* SB431542 and LDN193189 from Axon Medchem

Lombardo, V. A., Heise, M., Moghtadaei, M., Bornhorst, D., Männer, J., & Abdelilah-Seyfried, S. (2019). Morphogenetic control of zebrafish cardiac looping by Bmp signaling. Development, 146(22), dev180091.
https://journals.biologists.com/dev/article/146/22/dev180091/223166/Morphogenetic-control-of-zebrafish-cardiac-looping

Rostovskaya, M., Stirparo, G. G., & Smith, A. (2019). Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development, 146(7), dev172916.
https://journals.biologists.com/dev/article/146/7/dev172916/49126/Capacitation-of-human-naive-pluripotent-stem-cells

Eddowes, L. A., Al-Hourani, K., Ramamurthy, N., Frankish, J., Baddock, H. T., Sandor, C., ... & Boninsegna, S. (2019). Antiviral activity of bone morphogenetic proteins and activins. Nature microbiology, 4(2), 339.
https://www.nature.com/articles/s41564-018-0301-9

Song, W., Tung, C. K., Lu, Y. C., Pardo, Y., Wu, M., Das, M., ... & Ma, M. (2016). Dynamic self-organization of microwell-aggregated cellular mixtures. Soft matter, 12(26), 5739-5746.
http://pubs.rsc.org/-/content/articlehtml/2016/sm/c6sm00456c

Heesen, L., Peitz, M., Torres-Benito, L., Hölker, I., Hupperich, K., Dobrindt, K., ... & Hosseini-Barkooie, S. M. (2016). Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals. Cellular and molecular life sciences, 73(10), 2089-2104.
https://link.springer.com/article/10.1007/s00018-015-2084-y

Pfisterer, U., Ek, F., Lang, S., Soneji, S., Olsson, R., & Parmar, M. (2016). Small molecules increase direct neural conversion of human fibroblasts. Scientific reports, 6, 38290.
https://www.nature.com/articles/srep38290?WT.feed_name=subjects_stem-cell-research
(CHIR99021 and LDN193189 from Axon Medchem)

Jungverdorben, J., Evert, B. O., Peitz, M., Borghese, L., & Brüstle, O. Beate Roese-Koerner, Laura Stappert, Thomas Berger, Nils Christian Braun, Monika Veltel. (2016) Reciprocal Regulation between Bifunctional miR-9/9* and its Transcriptional
Modulator Notch in Human Neural Stem Cell Self-Renewal and
Differentiation. Stem Cell Reports. 2016, 7, 207.
http://www.cell.com/stem-cell-reports/pdfExtended/S2213-6711(16)30100-X

Osafune, Kenji, Takafumi Toyohara, and Yukiko Yamagishi. "METHOD FOR PRODUCING RENAL PROGENITOR CELLS, AND DRUG COMPRISING THE SAME." U.S. Patent No. 20,160,137,985. 19 May 2016.
http://www.freepatentsonline.com/y2016/0137985.html
*LDN193189 and Dorsomorphine

Matsuno, Kunihiko, et al. "Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells." Differentiation (2016).
http://www.sciencedirect.com/science/article/pii/S0301468116300238 

Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.
Lavoz, C., Alique, M., Rodrigues‐Diez, R., Pato, J., Keri, G., Mezzano, S., Egido, J., & Ruiz‐Ortega, M.
J. Pathol. 2015, online 19 MAY 2015. DOI: 10.1002/path.4537

Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling.
Watmuff, B., Hartley, B. J., Hunt, C. P., Fabb, S. A., Pouton, C. W., & Haynes, J. M.
Front Cell Neurosci. 2015, 9, 104. doi: 10.3389/fncel.2015.00104

Dullard/Ctdnep1 Regulates Endochondral Ossification via Suppression of TGF‐β Signaling.
Hayata, T., Asashima, M., Nishinakamura, R., & Noda, M.
J. Bone Mineral Res. 2015, 30(2), 318-329. DOI: 10.1002/jbmr.2343

2014
In vitro Differentiation of Pluripotent Stem Cells towards either Forebrain GABAergic or Midbrain Dopaminergic Neurons. Neural Stem Cell Assays, 91.
Hartley, B. J., Watmuff, B., Hunt, C. P.J., Haynes, J. M. and Pouton, C. W.
Neural Stem Cell Assays, 2014, 91 (eds N. Kaur and M. C. Vemuri), John Wiley & Sons, Inc, Hoboken, NJ, USA. doi: 10.1002/9781118308295.ch10
* SB431542 (Axon 1661), LDN193189 (Axon 1509) and DAPT (Axon 1484) were procured from Axon Medchem.
** Other two drugs used in this paper, CHIR99021 (Axon 1386) and Purmorphamine (Axon 1690), are also available at Axon Medchem.

ISOLATED NAIVE PLURIPOTENT STEM CELLS AND METHODS OF GENERATING SAME.
Hanna, Y., Novershtern, N., & Rais, Y. (2014). U.S. Patent No. 20,140,315,301. Washington, DC: U.S.
* about 30 inhibitors has been cited from Axon Medchem