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BAY R3401
Axon 4492
Recently added
CAS:
100276-03-7
Purity:
98%
- Soluble in DMSO and EtOH
- MF: C20H22ClNO4
- MW: 375.85
Description
BAY R3401 is a prodrug of BAY U6751 (Axon 4447), which is a glycogen phosphorylase (GPase) inhibitor with IC50 values of 39 nM and 138 nM for HLGPa and HMGPa, respectively. The metabolites of BAY R3401 suppress hepatic glycogenolysis by allosteric inhibition and by the dephosphorylation of phosphorylase a.
Key Features
- Prodrug of the GPase inhibitor BAY U6751
- Active metabolite inhibits HLGPa and HMGPa
- IC50: 39 nM (HLGPa) and 138 nM (HMGPa)
- Suppresses hepatic glycogenolysis
- Acts through allosteric inhibition and phosphorylase a dephosphorylation
Applications
- Glycogen phosphorylase research
- Glycogen metabolism studies
- Glucose homeostasis investigations
- Diabetes and hyperglycemia research
- Metabolic disease target validation studies
More Information
| Parent CAS No. | 100276-03-7 |
|---|---|
| Chemical Name | Isopropyl 7-(2-chlorophenyl)-4-ethyl-5-methyl-1-oxo-2-oxa-4-aza-1,3,4,7-tetrahydro-6-indenecarboxylate |
| SMILES | C1(C2C(Cl)=CC=CC=2)C(C(OC(C)C)=O)=C(N(CC)C2COC(=O)C1=2)C |
| MFCD | MFCD08705409 |
| InChi | InChI=1S/C20H22ClNO4/c1-5-22-12(4)16(20(24)26-11(2)3)17(13-8-6-7-9-14(13)21)18-15(22)10-25-19(18)23/h6-9,11,17H,5,10H2,1-4H3 |
| InChiKey | NPUSXSOBPNHOPH-UHFFFAOYSA-N |
| CID | 9842599 |
| Short Description | Gpase inhibitor |
BAY R3401
BAYR3401
BAY-R3401
GPase inhibitor
glycogen phosphorylase inhibitor
glycogen phosphorylase
GPase
GP
BAY U6751
prodrug
glycogen metabolism
hepatic glycogenolysis
glucose homeostasis
glycogen breakdown
hyperglycemia
diabetes
type 2 diabetes
metabolic disease
HLGPa
HMGPa
CAS 100276-03-7
Axon Medchem
Axon 4492
Glycogen
Prodrug
Enzymes
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Vendor
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