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BAY U6751
Axon 4447
Recently added
- Parent CAS: 320749-73-3
Purity:
99%
- Soluble in water, DMSO and EtOH
- MF: C20H20ClNNa2O6
- MW: 451.81
Description
BAY U6751 is a glycogen phosphorylase (GPase) inhibitor with IC50 values of 39 nM and 138 nM for HLGPa and HMGPa, respectively. Its prodrug, BAY R3401 (Axon 4492), is also available.
Key Features
- Potent glycogen phosphorylase inhibitor
- IC50: 39 nM for HLGPa
- IC50: 138 nM for HMGPa
- Suppresses glycogen breakdown and glycogenolysis
- Useful tool for glucose metabolism research
Applications
- Glycogen phosphorylase research
- Glycogen metabolism studies
- Glucose homeostasis investigations
- Diabetes and hyperglycemia research
- Metabolic disease target validation studies
More Information
| Parent CAS No. | 320749-73-3 |
|---|---|
| Chemical Name | 4-(2-Chlorophenyl)-1-ethyl-6-methyl-5-propan-2-yloxycarbonyl-4H-pyridine-2,3-dicarboxylate disodium |
| MFCD | MFCD08705410 |
| Short Description | Gpase inhibitor |
BAY U6751
BAY U 6751
BAY U-6751
GPase inhibitor
glycogen phosphorylase inhibitor
glycogen phosphorylase
GPase
GP
HLGPa
HMGPa
glycogen metabolism
glycogenolysis
glucose homeostasis
glucose metabolism
hepatic glucose production
hyperglycemia
diabetes
type 2 diabetes
metabolic disease
BAY R3401
prodrug
glycogen
CAS 320749-73-3
CAS 114290-51-6
Axon Medchem
Axon 4447
Enzymes
Supplier
Vendor
References
- SE Zographos et al.The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor. Structure. 1997 Nov 15;5(11):1413-25.
- AK Ogawa et al. Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3405-8.
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