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CU-CPT 4a
Axon 4482
Recently added
CAS:
1279713-77-7
- Optical Purity: 99% e.e.
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C18H13ClFNO3S
- MW: 377.82
Description
CU-CPT 4a is a potent and highly selective inhibitor of TLR3 signaling. Also, CU-CPT 4a repressed the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β. CU-CPT4a could prevent binding of dsRNA to TLR3 in murine macrophage RAW 264.7 cells with an IC50 of 3.44 μM.
Key Features
- Potent and selective TLR3 signaling inhibitor
- IC50: 3.44 μM in RAW 264.7 cells
- Blocks binding of dsRNA to TLR3
- Suppresses TNF-α and IL-1β expression
- Useful tool compound for innate immunity research
Applications
- TLR3 signaling pathway research
- Innate immune response studies
- Inflammation and cytokine signaling research
- dsRNA-mediated signaling studies
- Macrophage and immune cell biology research
More Information
| Parent CAS No. | 1279713-77-7 |
|---|---|
| Chemical Name | (R)-2-(3-Chloro-6-fluoro-1-benzothiophen-2-ylcarbonylamino)-3-phenylpropionic acid |
| SMILES | C1(Cl)=C(C(=O)N[C@@H](C(=O)O)CC2=CC=CC=C2)SC2C1=CC=C(F)C=2 |&1:6,r| |
| MFCD | MFCD27991282 |
| InChi | InChI=1/C18H13ClFNO3S/c19-15-12-7-6-11(20)9-14(12)25-16(15)17(22)21-13(18(23)24)8-10-4-2-1-3-5-10/h1-7,9,13H,8H2,(H,21,22)(H,23,24)/t13-/s3 |
| InChiKey | IAASQMCXDRISAV-VHLFKADZNA-N |
| CID | 53242268 |
| Short Description | Inhibitor of TLR3 signaling |
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