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PVP-057

Axon 4454
CAS:  946204-49-5
Purity:  98%
  • Soluble in DMSO
  • MF:  C23H22N4O5S2
  • MW:  498.58

Description

PVP-057 is a Toll-like receptor 3 (TLR3)-specific agonist active in both human in vitro models and mice in vivo. PVP-057 demonstrates in vivo murine adjuvanticity, enhancing the humoral and cellular immune responses to varicella-zoster virus glycoprotein E (VZV gE) antigen, SARS-CoV-2 spike protein, influenza virus recombinant hemagglutinin protein (rHA), herpes simplex virus 2 glycoprotein gD (HSV gD2), and cytomegalovirus glycoprotein B (CMV gB) as a single-component intramuscular (IM) or intradermal (ID) vaccine adjuvant.

Key Features

  • Selective TLR3 agonist
  • Active in human in vitro models and mice in vivo
  • Enhances humoral and cellular immune responses
  • Effective as a single-component vaccine adjuvant
  • Supports responses to viral vaccine antigens

Applications

  • TLR3 signaling and innate immunity research
  • Vaccine adjuvant development
  • Immunogenicity studies
  • Antiviral immune response research
  • Immunostimulatory and translational immunology studies

More Information

Parent CAS No. 946204-49-5
Chemical Name N-(4-((N-6-Ethoxy-1,3-benzothiazol-2-ylcarbamoyl)methyl)-1,3-thiazol-2-yl)3,5-dianisamide
SMILES C1(C(NC2=NC(CC(=O)NC3=NC4=CC=C(OCC)C=C4S3)=CS2)=O)=CC(OC)=CC(OC)=C1
InChi InChI=1S/C23H22N4O5S2/c1-4-32-15-5-6-18-19(11-15)34-23(25-18)26-20(28)9-14-12-33-22(24-14)27-21(29)13-7-16(30-2)10-17(8-13)31-3/h5-8,10-12H,4,9H2,1-3H3,(H,24,27,29)(H,25,26,28)
InChiKey QLPFDISZHHBMEC-UHFFFAOYSA-N
CID 26841966
Short Description TLR3 agonist

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