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IB-MECA
- Piclidenoson - CF101
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C18H19IN6O4
- MW: 510.29
Description
IB-MECA (Piclidenoson, CF101) is a potent and highly selective adenosine A3 receptor (A3AR) agonist with a Ki value of 1.1 nM. Selective activation of the A3 receptor modulates intracellular signaling pathways involved in inflammation, immune regulation, and cell survival, making IB-MECA one of the most widely used pharmacological tools for investigating A3 receptor biology.
The A3 adenosine receptor is a Gi protein-coupled receptor that regulates cyclic AMP signaling, MAPK pathways, NF-κB activity, and inflammatory cytokine production. Activation of A3 receptors has demonstrated anti-inflammatory, immunomodulatory, and tissue-protective effects in numerous experimental models. IB-MECA has been extensively investigated in preclinical and clinical studies for inflammatory diseases, autoimmune disorders, cancer, ischemic injury, and neuroprotection, making it a valuable research tool for studying adenosine signaling and GPCR pharmacology.
Key Features
- Potent and selective adenosine A3 receptor agonist
- Ki: 1.1 nM
- Activates Gi-coupled A3 receptor signaling
- Well-characterized pharmacological tool compound
- Extensively studied in inflammation, immunology, and oncology research
Applications
- Adenosine receptor pharmacology
- Inflammation and immune regulation research
- Autoimmune disease studies
- Cancer biology and tumor microenvironment research
- Neuroprotection and ischemia investigations
More Information
| Parent CAS No. | 152918-18-8 |
|---|---|
| Chemical Name | N-Methyl-(2S,3S,4R,5R)-5-(9a-((3-iodophenyl)methyl)-9-adenineyl)-3,4-dihydroxytetrahydro-2-furamide |
| SMILES | C1(=NC=NC2N([C@@H]3O[C@H](C(=O)NC)[C@@H](O)[C@H]3O)C=NC1=2)NCC1=CC(=CC=C1)I |&1:6,8,13,15,r| |
| MFCD | MFCD00671785 |
| InChi | InChI=1/C18H19IN6O4/c1-20-17(28)14-12(26)13(27)18(29-14)25-8-24-11-15(22-7-23-16(11)25)21-6-9-3-2-4-10(19)5-9/h2-5,7-8,12-14,18,26-27H,6H2,1H3,(H,20,28)(H,21,22,23)/t12-,13+,14-,18+/s3 |
| InChiKey | HUJXGQILHAUCCV-HOZBWTMTNA-N |
| CID | 123683 |
| Short Description | A3 agonist |
