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(S)-BI 2536
- Optical Purity: 100% e.e.
- Soluble in DMSO and EtOH
- MF: C28H39N7O3
- MW: 521.65
Description
(S)-BI 2536 is a dual PLK1 kinase/BRD4 bromodomain inhibitor with Ki values of 0.42 nM and 54 nM for PLK1 and BRD4, respectively. (S)-BI 2536 is the less active enantiomer of BI 2536 (Axon 1129, R-enantiomer).
More Information
| Parent CAS No. | 1241725-90-5 |
|---|---|
| Chemical Name | (S)-4-(8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide |
| SMILES | C1(NC2C=CC(C(NC3CCN(C)CC3)=O)=CC=2OC)N=C2N([C@H](C(=O)N(C)C2=CN=1)CC)C1CCCC1 |&1:23,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | PLK1/BRD4 inhibitor |
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