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MR-2088
Axon 4177
CAS:
2922531-69-7
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C19H17F3N4OS
- MW: 406.42
Description
MR-2088 is a best-in-class, potent and selective ULK1/2 inhibitor with a ULK1 binding/activity of 2 nM. MR-2088 blocks autophagy flux and synergizes with Trametinib (Axon 1761) to provide antiproliferative effects in NSCLC.
More Information
| Parent CAS No. | 2922531-69-7 |
|---|---|
| Chemical Name | 4-(2-(1,2,5,6-Tetrahydropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N-(2,2,2-trifluoroethyl)thiophene-2-carboxamide |
| SMILES | C12C=C(C3CNCCC=3)NC=1N=CC(C1=CSC(C(=O)NCC(F)(F)F)=C1)=C2 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H17F3N4OS/c20-19(21,22)10-25-18(27)16-6-14(9-28-16)13-4-12-5-15(26-17(12)24-8-13)11-2-1-3-23-7-11/h2,4-6,8-9,23H,1,3,7,10H2,(H,24,26)(H,25,27) |
| InChiKey | BEWNDCDAXDFYBH-UHFFFAOYSA-N |
| CID | 168198579 |
| Short Description | ULK1/2 inhibitor |
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