IPI-549
- Eganelisib
Axon 4147
CAS:
1693758-51-8
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C30H24N8O2
- MW: 528.56
Description
IPI-549 is a potent and isoform Gamma (γ ) selective phosphoinositide-3-kinase (PI3Kγ) Inhibitor (Kd = 0.29 nM), with biochemcial IC50 (nM) for PI3K isoforms: 3200 (α), 3500 (β), 16 (γ), and >8400 (δ), respectively and Cellular IC50 (nM) for PI3K isoforms: 250 (α), 240 (β), 1.2 (γ) and 180 (δ) respectively. It shows no significant inhibition for a panel of 468 mutant and non mutant protein and lipid kinases (including Class II PI3K isoforms) at 1 µM. IPI-549 demonstrates favorable pharmacokinetic properties and robust inhibition of PI3K-γ mediated neutrophil migration in vivo.
More Information
| Parent CAS No. | 1693758-51-8 |
|---|---|
| Chemical Name | (S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C2C=CC=C(C#CC3=CN(C)N=C3)C=2C(=O)N(C2C=CC=CC=2)C=1C(NC(=O)C1C(N)=NN2C=CC=NC=12)C |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | PI3Kγ inhibitor |
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