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Col003
Axon 3568
CAS:
328565-16-8
Purity:
99%
- Soluble in DMSO
- MF: C14H11NO4
- MW: 257.24
Description
Col003 is a potent, competitive collagen-heat-shock protein 47 (Hsp47) interaction inhibitor with an IC50 value of 1.8 μM.
More Information
| Parent CAS No. | 328565-16-8 |
|---|---|
| Chemical Name | 5-Benzyl-2-hydroxy-3-nitrobenzaldehyde |
| SMILES | C1(C=O)C(O)=C([N+]([O-])=O)C=C(CC2C=CC=CC=2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C14H11NO4/c16-9-12-7-11(6-10-4-2-1-3-5-10)8-13(14(12)17)15(18)19/h1-5,7-9,17H,6H2 |
| InChiKey | RKJXVCLOGNLZOI-UHFFFAOYSA-N |
| CID | 871077 |
| Short Description | HSP47 inhibitor |
References
- S Ito et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
- M Yoshida et al. Structure-Activity Relationship Study on Col-003, a Protein-Protein Interaction Inhibitor between Collagen and Hsp47. Chem Pharm Bull (Tokyo). 2020 Mar 1;68(3):220-226.
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