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HSP47 inhibitor III
- CBTC
Axon 3294
CAS:
287917-38-8
Purity:
98%
- Soluble in DMSO and EtOH
- MF: C8H6ClNO3S2
- MW: 263.72
Description
Inhibitor of the collagen-specific chaperone HSP47 with an IC50 value of 3.1 μM. HSP47 inhibitor III suppressed collagen type I expression in human and mouse cells and suppressed the viability and migration of lung fibroblasts.
More Information
| Parent CAS No. | 287917-38-8 |
|---|---|
| Chemical Name | Methyl 6-chloro-2-oxo-3H-1,2λ4,3-benzodithiazole-4-carboxylate |
| SMILES | C1C(C(OC)=O)=C2NS(=O)SC2=CC=1Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C8H6ClNO3S2/c1-13-8(11)5-2-4(9)3-6-7(5)10-15(12)14-6/h2-3,10H,1H3 |
| InChiKey | PLAIAIKZKCZEQF-UHFFFAOYSA-N |
| CID | 2726759 |
| Short Description | HSP47 inhibitor |
References
- CA Thomson et al. Identification of small molecule chemical inhibitors of the collagen-specific chaperone Hsp47. J Med Chem. 2005 Mar 10;48(5):1680-4.
- T Miyamura. Small molecule inhibitor of HSP47 prevents pro-fibrotic mechanisms of fibroblasts in vitro. Biochem Biophys Res Commun. 2020 Sep 24;530(3):561-565.
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