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ETC-206
Axon 3340
CAS:
1464151-33-4
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C25H20N4O2
- MW: 408.45
Description
ETC-206 is a potent, selective and orally available MNK1/2 inhibitor with IC50 values of 0.064 μM and 0.086 μM for MNK1 and MNK2, respectively. ETC-206 in combination with dasatinib (Axon 1392) prevents BC-CML LSC self-renewal in vitro and enhances dasatinib antitumor activity in vivo.
More Information
| Parent CAS No. | 1464151-33-4 |
|---|---|
| Chemical Name | 4-(6-(4-(Morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile |
| SMILES | O1CCN(C(=O)C2C=CC(C3C=CC4=NC=C(C5C=CC(C#N)=CC=5)N4C=3)=CC=2)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C25H20N4O2/c26-15-18-1-3-20(4-2-18)23-16-27-24-10-9-22(17-29(23)24)19-5-7-21(8-6-19)25(30)28-11-13-31-14-12-28/h1-10,16-17H,11-14H2 |
| InChiKey | FWRFPHJSGLYXTD-UHFFFAOYSA-N |
| CID | 71766360 |
| Short Description | MNK1/2 inhibitor |
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