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CGP 57380
Axon 1611
CAS:
522629-08-9
Purity:
99%
- Soluble in DMSO
- MF: C11H9FN6
- MW: 244.23
Description
CGP 57380 is an inhibitor of MAP kinase-interacting kinase 1 (MNK1/MKNK1) with selectivity over several upstream MAPK and Src-family kinases.
MNK1 phosphorylates eIF4E downstream of ERK and p38 signaling, linking MAPK pathways to cap-dependent translation. CGP 57380 is useful for investigating translational control, stress-response signaling and MNK-dependent cancer biology.
Key Features
- MNK1/MKNK1 inhibitor
- Blocks MAPK-dependent eIF4E phosphorylation pathways
- Displays selectivity over p38, JNK, ERK, PKC and c-Src family kinases
- Useful for translational control studies
Applications
- MNK1 kinase assays
- eIF4E phosphorylation research
- MAPK downstream signaling studies
- Cancer translation-control models
More Information
| Parent CAS No. | 522629-08-9 |
|---|---|
| Chemical Name | N3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine |
| SMILES | N(C1C=CC(F)=CC=1)C1=NNC2=NC=NC(N)=C12 |
| MFCD | MFCD03861062 |
| InChi | InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) |
| InChiKey | UQPMANVRZYYQMD-UHFFFAOYSA-N |
| CID | 11644425 |
| Short Description | Mnk1 inhibitor |
References
- U Knauf et al. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol. Cell Biol. 2001, 21(16), 5500-5511.
- K Andersson and R Sundler. Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages. Cytokine 2006, 33(1), 52-57.
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