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Dexamethasone
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C22H29FO5
- MW: 392.46
Description
Dexamethasone, an anti-inflammatory steroid, is a glucocorticoid receptor agonist. Dexamethasone was shown to have benefit in treatment of patients which are critically ill with COVID-19.
More Information
| Parent CAS No. | 50-02-2 |
|---|---|
| Chemical Name | (8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one |
| SMILES | C1=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@]4(C)[C@@](O)(C(CO)=O)[C@H](C)C[C@@]4([H])[C@]3([H])CCC2=CC1=O |&1:2,4,6,9,11,17,20,22,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1 |
| InChiKey | UREBDLICKHMUKA-CXSFZGCWSA-N |
| CID | 5743 |
| Short Description | Glucocorticoid agonist |
References
- GE Arth et al. 16-Methylated steroids. I. 16a-Methylated analogs of cortisone, a new group of anti-inflammatory steroids. J. Am. Chem. Soc. 1958, 80, 12, 3160-3161.
- H Ledford. Coronavirus breakthrough: dexamethasone is first drug shown to save lives. Nature. 2020 Jun;582(7813):469.
- CA LaLone et al. Effects of a glucocorticoid receptor agonist, dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22.
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