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ML-792
Axon 3109
CAS:
1644342-14-2
- Optical Purity: Optically pure
- Soluble in 0.1N NaOH(aq), 0.1N HCl(aq) and DMSO
- MF: C21H23BrN6O5S
- MW: 551.41
Description
ML-792 is a potent and selective SUMO-activating enzyme (SAE) inhibitor with IC50 values of 0.003 μM and 0.011 μM when SUMO1 or SUMO2 was used as the ubiquitin-like protein (UBL), respectively. ML-792 selectively blocks total SUMOylation, thus decreasing cancer cell proliferation.
More Information
| Parent CAS No. | 1644342-14-2 |
|---|---|
| Chemical Name | ((1R,2S,4R)-4-(5-(1-(3-Bromobenzyl)-1H-pyrazole-3-carbonyl)pyrimidin-4-ylamino)-2-hydroxycyclopentyl)methyl sulfamate |
| SMILES | C1(C(C2C=CN(CC3C=C(Br)C=CC=3)N=2)=O)C=NC=NC=1N[C@]1([H])C[C@H](COS(=O)(N)=O)[C@@H](O)C1 |&1:22,25,32,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H23BrN6O5S/c22-15-3-1-2-13(6-15)10-28-5-4-18(27-28)20(30)17-9-24-12-25-21(17)26-16-7-14(19(29)8-16)11-33-34(23,31)32/h1-6,9,12,14,16,19,29H,7-8,10-11H2,(H2,23,31,32)(H,24,25,26)/t14-,16-,19+/m1/s1 |
| InChiKey | PZCKLTWSXFDLLP-OGWOLHLISA-N |
| CID | 86566743 |
| Short Description | SAE inhibitor |
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