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TAK-981 oxalate
- Subasumstat oxalate
Axon 3797
- Parent CAS: 1858276-04-6
- Optical Purity: 0.99
- Soluble in DMSO
- MF: C25H28ClN5O5S2
- MW: 668.14
Description
TAK-981 oxalate is a first-in-class selective small molecule inhibitor of SUMOylation and an immuno-oncology agent. It targets and covalently binds to the small ubiquitin-like modifier (SUMO) protein, forming an adduct (TAK-981-SUMO adduct).
More Information
| Parent CAS No. | 1858276-04-6 |
|---|---|
| Chemical Name | ((1R,2S,4R)-4-(5-(4-((R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-ylamino)-2-hydroxycyclopentyl)methyl sulfamate oxalate |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(N[C@H]2C[C@H](O)[C@@H](COS(N)(=O)=O)C2)C(C(=O)C2SC(C)=C([C@@H]3NCCC4C=CC(Cl)=CC3=4)C=2)=CN=CN=1.OC(=O)C(=O)O |&1:2,4,6,22,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H28ClN5O5S2.C2H2O4/c1-13-18(23-19-7-16(26)3-2-14(19)4-5-29-23)9-22(37-13)24(33)20-10-28-12-30-25(20)31-17-6-15(21(32)8-17)11-36-38(27,34)35;3-1(4)2(5)6/h2-3,7,9-10,12,15,17,21,23,29,32H,4-6,8,11H2,1H3,(H2,27,34,35)(H,28,30,31);(H,3,4)(H,5,6)/t15-,17-,21+,23+;/m1./s1 |
| InChiKey | JPKHRLPOJXFPPS-GKXWFOPMSA-N |
| CID | 167530054 |
| Short Description | SUMOylation inhibitor |
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