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GKT137831
- Setanaxib - GKT831
Axon 3006
CAS:
1218942-37-0
Purity:
99%
- Soluble in DMSO
- MF: C21H19ClN4O2
- MW: 394.85
Description
GKT137831 is a first-in-class dual Nox1/4 inhibitor with Ki values of 110 nM and 140 nM for human Nox1 and Nox4, respectively. Moreover, GKT137831 is a potent inhibitor of fibrosis and hepatocyte apoptosis.
More Information
| Parent CAS No. | 1218942-37-0 |
|---|---|
| Chemical Name | 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione |
| SMILES | C1C=CC=C(N2C(=O)C3=C(C4C=CC=C(N(C)C)C=4)N(C)C(=O)C=C3N2)C=1Cl |
| MFCD | MFCD27923122 |
| InChi | InChI=1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3 |
| InChiKey | RGYQPQARIQKJKH-UHFFFAOYSA-N |
| CID | 58496428 |
| Short Description | Nox1/4 inhibitor |
References
- JX Jiang et al. Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free Radic Biol Med. 2012 Jul 15;53(2):289-96.
- T Aoyama et al. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology. 2012 Dec;56(6):2316-27.
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