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SEA0400
Axon 2751
CAS:
223104-29-8
Purity:
99%
- Soluble in DMSO
- MF: C21H19F2NO3
- MW: 371.38
Description
SEA0400 is a potent and selective inhibitor of the Na+-Ca2+ exchanger (NCX). IC50 values of SEA0400 were 33, 5.0, 8.3, 90 and 92 nM in cultured neurons, astrocytes, microglia, dog sarcolemmal vesicles and cultured rat myocytes, respectively. SEA0400 protects astrocytes against Ca2+ paradox-like injury and reduces cerebral ischemic damage in rats with a transient middle cerebral artery occlusion.
More Information
| Parent CAS No. | 223104-29-8 |
|---|---|
| Chemical Name | 2-(4-(2,5-Difluorobenzyloxy)phenoxy)-5-ethoxyaniline |
| SMILES | C1(F)C=C(COC2C=CC(OC3C(N)=CC(OCC)=CC=3)=CC=2)C(F)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3 |
| InChiKey | YSUBLPUJDOWYDP-UHFFFAOYSA-N |
| CID | 644100 |
| Short Description | NCX inhibitor |
References
- T Matsuda et al. SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther. 2001 Jul;298(1):249-56.
- H Tanaka et al. Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents. Br J Pharmacol. 2002 Mar;135(5):1096-100.
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