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YM-244769 dihydrochloride
Axon 3604
- Parent CAS: 838819-70-8
Purity:
98%
- Soluble in DMSO and EtOH
- MF: C26H22FN3O3.2HCl
- MW: 516.39
Description
YM-244769 dihydrochloride is a highly potent inhibitor of reverse NCX activity (IC50 value of 0.24 μM). Moreover, YM-244769 preferentially inhibited intracellular Na+-dependent 45Ca2+ uptake via NCX3 (IC50 value of 18 nM); the inhibition was 3.8- to 5.3-fold greater than for the uptake via NCX1 or NCX2, but it did not significantly affect extracellular Na+-dependent 45Ca2+ efflux via NCX isoforms. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.
More Information
| Parent CAS No. | 838819-70-8 |
|---|---|
| Chemical Name | N-(3-Aminobenzyl)-6-(4-(3-fluorobenzyloxy)phenoxy)nicotinamide dihydrochloride |
| SMILES | C1C=CC(COC2C=CC(OC3N=CC(C(=O)NCC4C=C(N)C=CC=4)=CC=3)=CC=2)=CC=1F.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C26H22FN3O3.2ClH/c27-21-5-1-4-19(13-21)17-32-23-8-10-24(11-9-23)33-25-12-7-20(16-29-25)26(31)30-15-18-3-2-6-22(28)14-18;;/h1-14,16H,15,17,28H2,(H,30,31);2*1H |
| InChiKey | OCKIUNLKEPKCRE-UHFFFAOYSA-N |
| CID | 90488952 |
| Short Description | NCX inhibitor |
References
- T Kuramochi et al. Synthesis and structure-activity relationships of 6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide derivatives as a novel class of NCX inhibitors: a QSAR study. Bioorg Med Chem. 2005 Feb 1;13(3):717-24.
- T Iwamoto et al. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol Pharmacol. 2006 Dec;70(6):2075-83.
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